In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Rui QinSchool of Pharmacy, Hospital of Chengdu University of Traditional Chinese Medicine, Lab for Innovation & Effective Uses of Chinese Drug Germplasm Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P.R. China.ORCID 0009-0009-7051-8570 Wei-Fang ZuoSchool of Pharmacy, Hospital of Chengdu University of Traditional Chinese Medicine, Lab for Innovation & Effective Uses of Chinese Drug Germplasm Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P.R. China.ORCID 0009-0007-3334-225X Ze-Hong ZhengSchool of Pharmacy, Hospital of Chengdu University of Traditional Chinese Medicine, Lab for Innovation & Effective Uses of Chinese Drug Germplasm Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P.R. China.ORCID 0009-0007-6531-8166 Jin ZhouSchool of Pharmacy, Hospital of Chengdu University of Traditional Chinese Medicine, Lab for Innovation & Effective Uses of Chinese Drug Germplasm Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P.R. China.
Jia-Xin LiSchool of Pharmacy, Hospital of Chengdu University of Traditional Chinese Medicine, Lab for Innovation & Effective Uses of Chinese Drug Germplasm Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P.R. China.
Gen ZhouSchool of Pharmacy, Hospital of Chengdu University of Traditional Chinese Medicine, Lab for Innovation & Effective Uses of Chinese Drug Germplasm Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P.R. China.
Hao HuangSchool of Pharmacy, Hospital of Chengdu University of Traditional Chinese Medicine, Lab for Innovation & Effective Uses of Chinese Drug Germplasm Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P.R. China.
Yan-Rong WeiSchool of Pharmacy, Hospital of Chengdu University of Traditional Chinese Medicine, Lab for Innovation & Effective Uses of Chinese Drug Germplasm Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P.R. China.
Cheng PengSchool of Pharmacy, Hospital of Chengdu University of Traditional Chinese Medicine, Lab for Innovation & Effective Uses of Chinese Drug Germplasm Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P.R. China.ORCID 0000-0003-3303-906X Qian-Qian YangSchool of Pharmacy, Hospital of Chengdu University of Traditional Chinese Medicine, Lab for Innovation & Effective Uses of Chinese Drug Germplasm Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P.R. China.ORCID 0000-0003-2890-1532 Bo HanSchool of Pharmacy, Hospital of Chengdu University of Traditional Chinese Medicine, Lab for Innovation & Effective Uses of Chinese Drug Germplasm Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P.R. China.ORCID 0000-0003-3200-4682 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Limited by the weaker d-p π-backdonation capacity exhibited by copper catalysis in metal carbene chemistry and the available carbene precursors, the construction of α-amino copper carbenes had remained unrealized. Here, we report a leaving group-driven carbene precursor design based on an intermolecular approach, enabling the generation and divergent transformations of pyrrole-type α-amino copper carbenes. This strategy successfully reversed the established protonation pathway of electron-rich enamine-copper complexes, effectively inverting the conventional polarity at the β position of the amine in the form of a pyrrole-type α-amino copper carbene. Furthermore, by leveraging the extensive library of ligands in copper catalysis, we have achieved fine-tuned, switchable stereo- and regioselective divergent synthesis. Through multiple classical carbene insertion reactions, as well as carbene oxidation and metathesis reactions, this approach enables the functionalization of the β position of amines with diverse nucleophilic groups.
Identifiers
PMID41512054
PMCPMC12787579
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