ArticleScience advances2026
NIR-switched DNA tweezer enables reversible miRNA recognition with erasable signal for in vivo continuous imaging.
Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Continuous monitoring of miRNA expression in vivo is crucial for understanding complex biological processes. However, current miRNA imaging probes suffer from irreversible responses, impairing their capabilities for real-time tracking concentration fluctuations. Here, we present a near-infrared regulated DNA tweezer (NIR-DNA tweezer) with reversible binding affinities to target miRNA. Self-quenched DNA tweezer is composed of BHQ3-labeled miRNA recognition strand and Cy5-labeled competitive strand, while competitive strand is embedded with azobenzene (Azo) to photo-switch the hybridization zones of DNA tweezer for reversible miRNA recognitions. NIR-DNA tweezer is obtained by conjugating DNA tweezer to upconversion nanoparticles, which is switched to "transit" status upon high-power 808-nm irradiation with
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