ArticleOrganic letters2026
Bifunctional Monothiosquaramide-Catalyzed Enantioselective Addition of Masked Acyl Cyanide to Isatins: Umpolung Strategy for the Total Synthesis of (
Francisco A A Reis, Manda Sathish, Bárbara V Silva, Roberta K F Marra, Letícia O Magalhães, Viresh H Rawal, Fabiane M Nachtigall, Leonardo S Santos
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In one paragraphArticle in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
Francisco A A ReisLaboratory of Asymmetric Synthesis, Chemistry Institute of Natural Resources Universidad de Talca Casilla 747, Talca 3460000, Chile.
Manda SathishCentro de Investigación de Estudios Avanzados del Maule, Vicerrectoría de Investigación y Postgrado Universidad Católica del Maule, Avenida San Miguel, Talca 3460000, Chile.
Bárbara V SilvaInstituto de Química, Universidade Federal do Rio de Janeiro, Avenida Athos da Silveira Ramos 149, Cidade Universitaria, Rio de Janeiro, Rio de Janeiro 21949-900, Brazil.
Roberta K F MarraInstituto de Química, Universidade Federal do Rio de Janeiro, Avenida Athos da Silveira Ramos 149, Cidade Universitaria, Rio de Janeiro, Rio de Janeiro 21949-900, Brazil.
Letícia O MagalhãesInstituto de Química, Universidade Federal do Rio de Janeiro, Avenida Athos da Silveira Ramos 149, Cidade Universitaria, Rio de Janeiro, Rio de Janeiro 21949-900, Brazil.
Viresh H RawalDepartment of Chemistry, University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, United States.ORCID 0000-0003-4606-0239 Fabiane M NachtigallInstituto de Ciencias Aplicadas Universidad Autónoma de Chile Talca 3467987, Chile.
Leonardo S SantosLaboratory of Asymmetric Synthesis, Chemistry Institute of Natural Resources Universidad de Talca Casilla 747, Talca 3460000, Chile.ORCID 0000-0002-1697-4200 Funding
New Methods and Strategies for the Concise Synthesis of Complex Indole AlkaloidsR01GM144663 · NIGMS · UNIVERSITY OF CHICAGO · PI RAWAL, VIRESH H. · 2021 to 2024
$1.3MMethods and Strategies for Concise Syntheses of Intricate Bioactive CompoundsR35GM158168 · NIGMS · UNIVERSITY OF CHICAGO · PI VIRESH H. RAWAL · 2025 to 2026
$850kNIGMS NIH HHS R01 GM144663NIGMS NIH HHS R35 GM158168
6 · The paper itselfAbstract
The enantioselective addition of masked acyl cyanide (MAC) to isatin is a highly efficient strategy for synthesizing bioactive chiral spirooxindoles. Herein, we report the utility of this strategy in an asymmetric total synthesis of (
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PMID41512048
PMCPMC13050229
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