Evidence map›Paper›PMID 41512027›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Distinct PlzC mechanisms integrate chemotaxis and c-di-GMP signaling to regulate

Jin Hwan Park, Emily N Kennedy, Sarvind Tripathi, Avery B Romp, Seth M Rubin, Robert B Bourret, Fitnat H Yildiz

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jin Hwan ParkDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA 95064.ORCID 0000-0001-8384-7909
Emily N KennedyDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599-7290.ORCID 0000-0002-5668-4339
Sarvind TripathiDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064.ORCID 0000-0002-6959-0577
Avery B RompDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599-7290.
Seth M RubinDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064.ORCID 0000-0002-1670-4147
Robert B BourretDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599-7290.ORCID 0000-0002-6666-9220
Fitnat H YildizDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA 95064.ORCID 0000-0002-6384-7167

Funding

Molecular Mechanisms of Signal Transduction by Two-Component Regulatory SystemsR01GM050860 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOURRET, ROBERT B. · 1994 to 2025
$7.9M
Molecular Mechanisms of Cell Cycle Dependent Gene ExpressionR35GM145255 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Seth Michael Rubin · 2022 to 2026
$3.0M
Mechanisms and Consequences of c-di-GMP Control of Motility and Biofilm FormationR01AI189907 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Havva Fitnat Yildiz · 2025 to 2026
$1.6M
Vibrio cholerae c-diGMP signaling: Motile to biofilm transition and transmissionR37AI102584 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Havva Fitnat Yildiz · 2025 to 2026
$1.5M
BSLII Stationed Zeiss 880 Confocal Microscope with AiryscanS10OD023528 · OD · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI YILDIZ, HAVVA FITNAT · 2017 to 2017
$456k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI189907HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R37AI102584HHS | NIH | National Institute of General Medical Sciences (NIGMS) R01GM050860HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM145255NIAID NIH HHS R01 AI189907NIAID NIH HHS R37 AI102584NIGMS NIH HHS R01 GM050860NIGMS NIH HHS R35 GM145255NIH HHS S10 OD023528ODCDC CDC HHS S10 OD023528
6 · The paper itself

Abstract

Bacterial motility and biofilm formation are essential for the adaptation and survival of

Indexed as

Bacterial ProteinsBiofilmsChemotaxisCyclic GMPSignal TransductionVibrio choleraeGene Expression Regulation, BacterialPhosphoric Monoester HydrolasesBacterial Proteinsbis(3',5')-cyclic diguanylic acidCyclic GMPPhosphoric Monoester Hydrolasesbiofilmc-di-GMPchemotaxisPilZ domainVibrio cholerae

Identifiers

PMID41512027
PMCPMC12799141

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.