Evidence map›Paper›PMID 41511950›Full record

ArticlePloS one2026

A deep learning model to enhance lung cancer detection using 'Dual-Branch' model classification approach.

Emad Shweikeh, Murad Al-Rajab, Joan Lu, Qiang Xu, Mike Joy, Abderahman Ahmed, Hong Chang

Abstract read
In one paragraph

Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Emad ShweikehDepartment of Computer Science, School of Computing and Engineering, University of Huddersfield, Huddersfield, United Kingdom.ORCID https://orcid.org/0009-0002-6164-7580
Murad Al-RajabComputer Science and IT Department, College of Engineering, Abu Dhabi University, Abu Dhabi, United Arab Emirates.
Joan LuLeeds Beckett University, Leeds, United Kingdom.
Qiang XuDepartment of Computer Science, School of Computing and Engineering, University of Huddersfield, Huddersfield, United Kingdom.
Mike JoyDepartment of Computer Science, University of Warwick, Coventry, United Kingdom.
Abderahman AhmedDepartment of Electronic Engineering, University of Seville, Seville, Spain.
Hong ChangOxford MEStar Ltd, Yarnton, England.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer remains a life-threatening global challenge, with lung cancer ranking among the most devastating forms, impacting millions annually. Early detection and accurate classification are essential for improving patient survival rates, and computed tomography (CT) has become a critical tool in lung cancer diagnosis. Despite advancements, previous studies have faced notable challenges, particularly a shortage of available samples and limitations in input modalities, both of which hinder model performance. Addressing these issues, this research introduces the Dual-Branch Model Classification Approach (DbMCA), a two-stage strategy that integrates image and mask data to enhance detection accuracy and scalability. Two comparative experiments were conducted using the LIDC-IDRI dataset with varying data sizes to evaluate the impact of sample size and dual-input modalities. The DbMCA achieved remarkable results, as it performed higher accuracy results a 91.21% accuracy and 91.18% F1-score in the smaller dataset and an exceptional 98.04% accuracy and 98.01% F1-score in the larger dataset. CNN performance on sparse mask data declines with scale, while DNN and SVM consistently outperform it, highlighting architecture sensitivity to sparsity. This demonstrates the model's improved discriminative power and potential for detecting subtle lung cancer patterns, however, based on statistical evidence DbMCA significantly outperforms weaker baselines and successfully integrates multi-modal information. Nonetheless, certain limitations were observed, such as the high computational requirements stemming from large sample sizes, the constrained information provided by segmentation masks, and the presence of potential biases in the dataset. These challenges hinder the model's ability to generalize effectively. Future research should aim to enhance image quality, broaden the scope of datasets, and overcome segmentation-related constraints to make further progress in lung cancer detection. The DbMCA represents a significant step forward in improving the performance and scalability of diagnostic tools, offering the potential for more effective and lifesaving interventions in lung cancer care.

Indexed as

Deep LearningLung NeoplasmsAlgorithmsClassification AlgorithmsConvolutional Neural NetworksHumansTomography, X-Ray Computed

Identifiers

PMID41511950
PMCPMC12788669

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.