ArticlePsychotherapy and psychosomatics2026
Short-Term Psychodynamic Therapy of Obsessive-Compulsive Disorder: A Randomized Controlled Trial of Unmedicated Patients.
Article in Psychotherapy and psychosomatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionObsessive-compulsive disorder (OCD) is an often chronic and disabling mental disorder. Cognitive-behavioral therapy and serotonin-reuptake inhibitors and their combination are first-line treatments. However, about 50% of the patients do not achieve response or remission, although many patients received additional pharmacotherapy. These results highlight the need for additional evidence-based treatment options.
methodsIn a randomized controlled trial (RCT), a manual-guided method of short-term psychodynamic therapy (STPP) for OCD was tested against a waiting list condition. Thirty-seven unmedicated patients were randomly assigned to STPP, 30 to the waiting list. The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) total score post-therapy assessed by trained and masked raters was the primary outcome. Secondary outcomes included response, remission, depression, interpersonal problems, and obsessive beliefs.
resultsIn the intention-to-treat sample, STPP achieved a significantly lower Y-BOCS score (p < 0.0001) than the waiting list condition, associated with a large between-group effect size (d = 1.04). The mean difference of change in the Y-BOCS between baseline and post-therapy or waiting period assessment was -11.49 (95% CI -14.36, -8.63) for STPP and -1.10 (95% CI -4.29, 2.10) in the waiting list. Remission rates were 60% vs. 20% (p = 0.0006), response rates 64% vs. 16% (p = 0.0003) in favor of STPP.
conclusionIn a first RCT, manual-guided STPP proved to be efficacious in OCD with a clinically meaningful improvement, thereby broadening the spectrum of evidence-based interventions. Of note, our study is one of the few trials using psychotherapy as a monotherapy in OCD, showing effects of psychotherapy alone. Further research is needed to confirm these first findings and to compare STPP with other established treatments.
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