Observational studyCritical care explorations2026
Ketamine for Severe Asthma Exacerbation.
Observational study in Critical care explorations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to evaluate ventilator requirements, gas exchange, and safety outcomes before and after initiation of continuous infusion ketamine in intubated patients with severe asthma exacerbations (SAEs) in ICUs. This retrospective observational study included 38 intubated patients 18 years old or older experiencing an SAE who received a continuous infusion of ketamine for greater than or equal to 1 hour. The primary outcome was change in Pco2 before and after ketamine initiation. The median Pco2 before ketamine initiation was 67.65 mm Hg (56-81 mm Hg) and 64 mm Hg (56-77 mm Hg) after. The median pH before and after ketamine initiation was 7.21 (7.12-7.3) and 7.24 (7.14-7.3), respectively. The median maximum rate of ketamine was 1.2 mg/kg/hr (0.7-1.5 mg/kg/hr). Mortality occurred in 15.8% of patients. Tachycardia occurred in 52.6% of patients, and hypotension occurred in 50% of patients. The rate of emergence reactions was 13.2%. In this study, continuous infusion ketamine was not associated with an improvement in Pco2.
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