Evidence map›Paper›PMID 41511721›Full record

ReviewMolecular and cellular biochemistry2026

Advances in the application of spatial transcriptomics in understanding development and disease.

Yao Li, Qian-Wen Zheng, Mingpeng Li, Jing Chen, Lin-Yong Zhao

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular and cellular biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yao Li *Department of Pediatric Surgery and Laboratory of Pediatric Surgery, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China.
Qian-Wen Zheng *Department of Pediatric Surgery and Laboratory of Pediatric Surgery, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China.
Mingpeng Li *State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Jing ChenDepartment of Pediatric Surgery and Laboratory of Pediatric Surgery, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China. jingchen@scu.edu.cn.
Lin-Yong ZhaoDepartment of General Surgery & Laboratory of Gastric Cancer, West China Hospital, State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy and Cancer Center, Sichuan University, Chengdu, China. 153795352@scu.edu.cn.ORCID http://orcid.org/0000-0003-0884-4657

Funding

Sichuan Science and Technology Program No.2025ZNSFSC0715.
6 · The paper itself

Abstract

Spatial transcriptomics (In this review, 'spatial transcriptomics' (ST) is employed as a overarching term, encompassing two distinct concepts. Firstly, 'tissue-level ST' refers to the capture of tissue samples at a resolution of 10-100 μm, encompassing 1-20 cells. Secondly, 'spatially resolved single-cell transcriptomics' (sc-ST) involves the analysis of individual cells or nuclei, with each sequencing unit measuring ≤ 2 μm) fuses high-throughput sequencing with positional information to map gene expression within intact tissues. By preserving spatial context, the technology uncovers cell types, signaling circuits and regulatory networks that drive organogenesis, differentiation and disease. Here we synthesize recent methodological advances and their application to developmental and clinical questions. The term "Spatial Transcriptomics" as used in this paper comprehensively encompasses all sequencing technologies that preserve spatial coordinates, including multimodal data such as transcriptomics (RNA), genomics (DNA), epigenomics (ATAC, CUT&Tag), and translationalomics (Ribo-seq).

Indexed as

TranscriptomeAnimalsHumansSpatial TranscriptomicsDevelopmental biologyDiseaseSpatial transcriptomics

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.