ReviewMolecular diversity2026
Advances in 1,3,4-thiadiazole-based cholinesterase inhibitors: toward novel therapeutics for Alzheimer's disease.
Review in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder in which cholinergic dysfunction plays a central role. Inhibition of acetylcholinesterase and butyrylcholinesterase remains a validated therapeutic approach for managing AD symptoms. Over the past decade (2015-2025), 1,3,4-thiadiazole derivatives have gained considerable attention as promising scaffolds for cholinesterase inhibition owing to their favorable electronic configuration, hydrogen-bonding potential, and metabolic stability. This review comprehensively analyzes recent progress in the synthesis and biological evaluation of 1,3,4-thiadiazole-based cholinesterase inhibitors, with an emphasis on structure-activity relationship trends supported by molecular docking insights. Substitution with electron-withdrawing or heteroaryl groups has been found to enhance the binding affinity toward AChE and BuChE, while some derivatives also exhibit activity against carbonic anhydrase, α-glucosidase, α-amylase, and antioxidant systems, reflecting scaffold versatility. This review further highlights the docking interactions with catalytic residues that validate the observed experimental potency. Finally, key limitations and future directions are discussed, emphasizing rational structure modification, computationally guided design, and green synthetic approaches to develop brain-penetrant and pharmacologically optimized 1,3,4-thiadiazole-based anti-Alzheimer's agents.
Indexed as
Identifiers
41511689What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.