Evidence map›Paper›PMID 41511687›Full record

ArticleMolecular diversity2026

One-pot synthesis and biological evaluation of substituted 7-chloroindolizines as antimicrobial, antioxidant, and anti-inflammatory agents.

Priya Tiwari, Shweta Tripathi, Raghu Ningegowda, Govinakere Mallegowda Dhanush, H K Vivek, Sandeep Chandrashekharappa

Abstract read
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In one paragraph

Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Priya Tiwari *Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Raebareli, Transit Campus, Bijnor-Sisendi Road, Sarojini Nagar, Near CRPF Base Camp, Lucknow, UP, 226002, India.
Shweta Tripathi *Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Raebareli, Transit Campus, Bijnor-Sisendi Road, Sarojini Nagar, Near CRPF Base Camp, Lucknow, UP, 226002, India.
Raghu NingegowdaDepartment of Chemistry, Jyoti Nivas College Autonomous, Koramangala 5th Block, Bangalore, 560095, India. raghu.ningegowda80@gmail.com.
Govinakere Mallegowda DhanushDepartment of Biotechnology, Adichunchanagiri School of Natural Sciences, B.G Nagara, Nagamangala, Mandya, 571448, India.
H K VivekDepartment of Biotechnology, Adichunchanagiri School of Natural Sciences, B.G Nagara, Nagamangala, Mandya, 571448, India.
Sandeep ChandrashekharappaDepartment of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Raebareli, Transit Campus, Bijnor-Sisendi Road, Sarojini Nagar, Near CRPF Base Camp, Lucknow, UP, 226002, India. c.sandeep@niperraebareli.edu.in.

Funding

UPSCT CST/CHEM/D-679, Project ID- 4041
6 · The paper itself

Abstract

An efficient one-pot synthetic strategy has been developed for the construction of substituted 7-chloroindolizine derivatives using 4-chloropyridine hydrochloride (1) and substituted phenacyl bromides 2(a-i) as key starting materials. The reaction proceeds via a cascade cyclization under mild and operationally simple conditions, affording a structurally diverse library of indolizine (4a-l) frameworks excellent to good yields. The synthesized compounds were rigorously characterized by

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsAnti-Inflammatory AgentsAntioxidantsIndolizinesCyclooxygenase 2Escherichia coliMicrobial Sensitivity TestsMolecular Docking SimulationStaphylococcus aureusStructure-Activity RelationshipAnti-Bacterial AgentsAnti-Infective AgentsAnti-Inflammatory AgentsAntioxidantsCyclooxygenase 2Indolizines7-ChloroindolizinesAntibacterialAntioxidantCOXMolecular docking

Identifiers

PMID41511687

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.