Evidence map›Paper›PMID 41511678›Full record

ArticleTissue engineering and regenerative medicine2026

Twin Glomeruli: a Newly Discovered Marker of Neonephrogenesis in the Ischemia-Reperfusion Injured Adult Mouse Kidney.

Hanguk Hwang, Dongju Woo, You Ri Park, Min Jung Kong, Heedong Lee, Kwon Moo Park, Yong Seok Nam, Je-Yong Choi, Sungwook Nam, Eon Jung Nam and 6 more

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Article in Tissue engineering and regenerative medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

16 authors.

Hanguk HwangDepartment of Anatomy, School of Medicine, Kyungpook National University, (41944) 680 Gukchaebosang-ro, Jung-gu, Daegu, South Korea.
Dongju WooDepartment of Anatomy, School of Medicine, Kyungpook National University, (41944) 680 Gukchaebosang-ro, Jung-gu, Daegu, South Korea.
You Ri ParkDepartment of Anatomy, School of Medicine, Kyungpook National University, (41944) 680 Gukchaebosang-ro, Jung-gu, Daegu, South Korea.
Min Jung KongDepartment of Anatomy, School of Medicine, Kyungpook National University, (41944) 680 Gukchaebosang-ro, Jung-gu, Daegu, South Korea.
Heedong LeeDepartment of Anatomy, School of Medicine, Kyungpook National University, (41944) 680 Gukchaebosang-ro, Jung-gu, Daegu, South Korea.
Kwon Moo ParkDepartment of Anatomy, School of Medicine, Kyungpook National University, (41944) 680 Gukchaebosang-ro, Jung-gu, Daegu, South Korea.
Yong Seok NamDepartment of Anatomy, School of Medicine, Kyungpook National University, (41944) 680 Gukchaebosang-ro, Jung-gu, Daegu, South Korea.
Je-Yong ChoiDepartment of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, South Korea.
Sungwook NamDepartment of Molecular Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Eon Jung NamDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Sun-Hee ParkDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Hongtae KimDepartment of Anatomy, School of Medicine, Daegu Catholic University, Daegu, South Korea.
Sang Yeon LeeDepartment of Applied Chemistry, College of Engineering, Kyungpook National University, Daegu, South Korea.
Soo Ho LeeDepartment of General Surgery, Bundang Jesaeng Hospital, Seongnam, South Korea.
Jeong Ok LimWake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Mae Ja ParkDepartment of Anatomy, School of Medicine, Kyungpook National University, (41944) 680 Gukchaebosang-ro, Jung-gu, Daegu, South Korea. mjpark@knu.ac.kr.ORCID http://orcid.org/0000-0002-4753-8217

Funding

National Research Foundation of Korea 2021M3A9H3016063National Research Foundation of Korea 2022R1A2C1006105National Research Foundation of Korea 2022R1F1A1074842
6 · The paper itself

Abstract

backgroundThe renal glomerulus, a capillary network between two arterioles, is essential for urine production in mammals. While it partially regenerates after renal injury, its precise mechanisms remain unclear, and stereological studies on post-injury glomerular structural changes are limited.

methodsTherefore, this study aims to investigate three-dimensional glomerular alterations over time following ischemia-reperfusion injury (IRI) in adult mouse kidneys. Synchrotron radiation micro-computed tomography (SR-MCT) and immunohistochemical analyses were employed to visualize and quantify three-dimensional glomerular structures and nephron numbers from 1 to 21 days post-IRI.

resultsA unique "twin glomeruli" structure, linked to three arterioles through an atypical "aefferent" arteriole, appeared between 3 and 21 days post-IRI, peaked on day 9, and exhibited features distinct from both degenerating and developing glomeruli. SR-MCT revealed a time-dependent increase in nephron numbers between 1 and 21 days post-IRI, while immunohistochemistry revealed significant elevated glomerular and tubular densities from days 9 to 21. These findings suggest that twin glomeruli are transient structures induced by IRI and may contribute to nephron expansion.

conclusionThis study challenges current understanding by demonstrating that twin glomeruli represent an atypical glomerular structure occurring during kidney repair and suggesting possible neonephrogenesis in the adult mouse kidney, a phenomenon previously considered impossible after birth. If similar results are observed in humans, it could lead to significant changes in the approaches and objectives for treating renal diseases. Additionally, a comprehensive investigation into the numerical response of glomerular counts to various stimuli could provide valuable insights into kidney regeneration and repair.

Indexed as

Kidney GlomerulusOrganogenesisReperfusion InjuryAnimalsBiomarkersImmunohistochemistryMaleMiceMice, Inbred C57BLNephronsX-Ray MicrotomographyBiomarkersAdult mouse kidneyGlomerulogenesisNeonephrogenesisRenal ischemia/reperfusion injurySynchrotron radiation micro-computed tomographyTwin glomeruli

Identifiers

PMID41511678
PMCPMC12855688

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.