Evidence map›Paper›PMID 41511675›Full record

ArticleEJNMMI research2026

Head-to-head comparison of [

Circe D van der Heide, Carolline M Ntihabose, Mark Konijnenberg, Hanyue Ma, Debra Stuurman, Corrina de Ridder, Yann Seimbille, Michail C Doukas, Erik de Blois, Simone U Dalm

Abstract read
In one paragraph

Article in EJNMMI research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Evaluation of treatment efficacy of theEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Progress in the application ofAnnals of nuclear medicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Circe D van der HeideDepartment of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
Carolline M NtihaboseDepartment of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
Mark KonijnenbergDepartment of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
Hanyue MaDepartment of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
Debra StuurmanDepartment of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
Corrina de RidderDepartment of Experimental Urology, Erasmus MC, Rotterdam, The Netherlands.
Yann SeimbilleDepartment of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
Michail C DoukasDepartment of Pathology, Erasmus MC, Rotterdam, The Netherlands.
Erik de BloisDepartment of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
Simone U DalmDepartment of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands. s.dalm@erasmusmc.nl.ORCID http://orcid.org/0000-0002-6393-6901

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTerbium-161 (Tb-161) emits internal conversion and Auger electrons, in addition to beta-minus radiation, which might be of added benefit for targeted radionuclide therapy (TRT) compared to Lutetium-177 (Lu-177). We extensively compared Lu-177 and Tb-161 for fibroblast activation protein (FAP)- TRT in a preclinical setting. To study this, FAP-2286 was labeled with Lu-177 and Tb-161 and characterized in vitro on FAP-expressing cells and ex vivo using patient tumor samples. Moreover, in vivo studies (i.e. biodistribution and efficacy) were performed using a clinically representative pancreatic ductal adenocarcinoma (PDAC) mouse model. Biodistribution was performed 1, 4, 24, and 48 h post injection of 5 MBq/500 pmol [

resultsNo difference in [

conclusionsIn our in vitro and in vivo studies, [

Indexed as

Cancer-associated fibroblast (CAF)Fibroblast activation protein (FAP)Pancreatic ductal adenocarcinoma (PDAC)Targeted radionuclide therapy (TRT)Terbium-161

Identifiers

PMID41511675
PMCPMC12891299

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.