Evidence map›Paper›PMID 41511654›Full record

ArticleRice (New York, N.Y.)2026

Genome-Wide Association and Transcriptome Analyses Identify OsCBP606 as a Calmodulin-Mediated Susceptibility Gene to Magnaporthe oryzae in Rice.

Zhikai Han, Wenyu Lu, Shengyi Chen, Qiwei Huang, Huabin Xie, Chengye Sun, Jiayang Li, Renhui Li, Xiaodi Zou, Wenjie Zhou and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Rice (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Zhikai HanNational Plant Space Breeding Engineering Technology Research Center, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Wenyu LuNational Plant Space Breeding Engineering Technology Research Center, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Shengyi ChenNational Plant Space Breeding Engineering Technology Research Center, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Qiwei HuangNational Plant Space Breeding Engineering Technology Research Center, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Huabin XieNational Plant Space Breeding Engineering Technology Research Center, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Chengye SunNational Plant Space Breeding Engineering Technology Research Center, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Jiayang LiNational Plant Space Breeding Engineering Technology Research Center, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Renhui LiNational Plant Space Breeding Engineering Technology Research Center, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Xiaodi ZouNational Plant Space Breeding Engineering Technology Research Center, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Wenjie ZhouNational Plant Space Breeding Engineering Technology Research Center, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Danhong WeiNational Plant Space Breeding Engineering Technology Research Center, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Chun ChenNational Plant Space Breeding Engineering Technology Research Center, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Tao GuoNational Plant Space Breeding Engineering Technology Research Center, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Jiafeng WangNational Plant Space Breeding Engineering Technology Research Center, South China Agricultural University, Guangzhou, 510642, Guangdong, China. jfwang@scau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rice blast, caused by the fungus Magnaporthe oryzae, is one of the most devastating diseases that affects rice production globally. Identifying new QTLs or R genes for blast resistance is crucial for developing rice varieties with enhanced resistance. In this study, a genome-wide association study (GWAS) to identify QTLs associated with blast resistance was conducted using phenotypic and genotypic data from 236 rice accessions. A total seven important QTLs linked to rice blast resistance were identified on chromosomes 1, 5, 6, 7, 10, and 12. Four main QTLs (qMZ6.1, qMZ7.1, qMZ10.1, and qMZ12.1) were key contributors to the blast resistance. Through combined analysis of differential expression and annotations of the predicted genes within qMZ12.1 based on haplotype and disease phenotype, we identified OsCBP606, which encodes a calmodulin protein, as the candidate gene for qMZ12.1. Compared with the wild-type plants, OsCBP606 knockout plants exhibited enhanced resistance to M. oryzae, while OsCBP606 overexpressing plants showed increased susceptibility. These findings highlight the critical role of OsCBP606 in modulating the rice immune response, making it a promising target for breeding programs aimed at improving rice blast resistance.

Indexed as

Calmodulin proteinGenome-wide association studyMagnaporthe oryzaeRice blastRNA-seq

Identifiers

PMID41511654
PMCPMC12881197

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.