Trial reportAging clinical and experimental research2026
Combined creatine and β-hydroxy-β-methylbutyrate supplementation with integral conditioning exercise enhances functional performance and metabolic health in physically active older adults: A randomized controlled crossover trial.
Trial report in Aging clinical and experimental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCombined creatine monohydrate (CRE) and β-hydroxy-β-methylbutyrate (HMB) supplementation may counteract age-related declines in functional capacity, yet evidence in physically active older adults is scarce.
objectiveTo investigate the effects of six weeks of CRE + HMB supplementation integrated with a supervised multicomponent exercise program on functional performance, metabolic efficiency, and physiological health in older adults.
methodsThirty physically active adults aged ≥ 60 years (20 men, 10 women) completed a randomized, double-blind, placebo-controlled crossover trial involving two 6-week intervention phases (CRE + HMB or placebo), separated by a 3-week washout. The exercise program (4 sessions/week) combined strength, endurance, and coordination training. Functional tests (4-m gait speed, 5-repetition sit-to-stand, Timed Up and Go, 400-m walk), metabolic indices, and cardiopulmonary and inflammatory markers were assessed pre- and post-intervention.
resultsCRE + HMB significantly improved gait speed, sit-to-stand, TUG, and 400-m walk (p < 0.05), with large effect sizes (η²p = 0.15–0.29). Basal metabolic rate and metabolic rate index increased, while visceral adiposity showed favorable trends. Women exhibited reductions in diastolic blood pressure and higher expiratory strength; men showed a transient rise in endothelial protein C receptor (EPCR). No period, sequence, or carryover effects were detected.
conclusionsSix weeks of CRE + HMB supplementation integrated with supervised multicomponent training enhanced mobility, metabolic efficiency, and selected physiological outcomes in physically active older adults. This strategy represents a safe, feasible, and practical approach to sustain functional independence and metabolic health with aging.
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