ArticleApplied biochemistry and biotechnology2026
Acupuncture Inhibits Ferroptosis to Attenuate Cerebral Ischemia-Reperfusion Injury Through FTO-Mediated m6A Modification of ACSL4.
Article in Applied biochemistry and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Acupuncture, a traditional Chinese medical intervention, is extensively utilized in the management of ischemic stroke across its various stages. However, the precise mechanisms underlying its therapeutic action are not fully elucidated. The present study sought to investigate the therapeutic effects and unravel the potential mechanisms of Xingnao Kaiqiao (XNKQ) acupuncture in ameliorating cerebral ischemia-reperfusion injury (CIRI). We established a rat model of middle cerebral artery occlusion (MCAO) and administered both Xingnao Kaiqiao (XNKQ) acupuncture and non-acupoint acupuncture as interventions. Neurobehavioral scoring and TTC staining were employed to evaluate the efficacy of acupuncture in improving CIRI. Our findings indicated that XNKQ acupuncture significantly enhanced neurological function and decreased the volume of cerebral infarction in rats. Western blot, quantitative real-time PCR (RT-qPCR), dot blot, and kit assays were utilized to assess the impact of acupuncture on ferroptosis and m6A methylation. The data revealed that XNKQ acupuncture diminished the levels of ACSL4 and the ferroptosis-associated markers MDA and Fe
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