ArticleBulletin of experimental biology and medicine2025
Anxiolytic Effect of GHK-PGP Peptide and Its Structural Analogues in a Test with Punished Behavior.
Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Extracellular Matrix-Derived Matrikines: Circulating Peptides as Candidate Mediators of Lung-to-Brain Signaling.International journal of molecular sciences · 2026Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The anxiolytic effects of Gly-His-Lys-Pro-Gly-Pro peptide (GHK-PGP) and its proline-containing analogs were studied in a test with punished behavior. Peptides Gly-His-Lys (GHK), Pro-Gly-Pro (PGP), GHK-PGP, Gly-His-Lys-Gly-Pro (GHK-GP), and Gly-His-Lys-Pro (GHK-P) were used. Anxiolytic activity was assessed in the Vogel conflict test. The peptide GHK had no anxiolytic effect, while PGP and GHK-PGP produced an anxiolytic effect in certain doses. Presumably, the anxiolytic effect of the peptide GHK-PGP is determined by the action of PGP in the absence of the blocking effect of GHK. The peptides GHK-P and GHK-GP also had anxiolytic effects, which may indicate the presence of anxiolytic activity in various proline-containing amino acid sequences attached to GHK.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.