Evidence map›Paper›PMID 41511537›Full record

ReviewNaunyn-Schmiedeberg's archives of pharmacology2026

Platelet-derived non-coding RNAs as emerging contributors to autoimmune inflammation.

Amr Ali Mohamed Abdelgawwad El-Sehrawy, Raed Obaid Saleh, Abdullah Ali Alzahrani, Mohammed Asiri, Subbulakshmi Ganesan, Mayank Kundlas, Premkumar J, Subhashree Ray, Ahmad Hussein, Mohammed Jawad Alnajar

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In one paragraph

Review in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Amr Ali Mohamed Abdelgawwad El-SehrawyInternal Medicine Department, Diabetes, Endocrinology and Metabolism, Mansoura University, Mansoura, Egypt. amr.a.m.a.elsehrawy@gmail.com.
Raed Obaid SalehDepartment of Medical Laboratories Techniques, College of Health and Medical Techniques, University of Al Maarif, Al Anbar, 31001, Iraq. Dr.raed.obaid@uoa.edu.iq.
Abdullah Ali AlzahraniOrthopedic Surgery Department, Taif University, Taif, Saudi Arabia.
Mohammed AsiriDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
Subbulakshmi GanesanDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to Be University), Bangalore, Karnataka, India.
Mayank KundlasCentre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, 140401, Punjab, India.
Premkumar JDepartment of Biomedical, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, India.
Subhashree RayDepartment of Biochemistry, IMS and SUM Hospital, Siksha 'O' Anusandhan (Deemed to Be University), Bhubaneswar, Odisha, 751003, India.
Ahmad HusseinDepartment of Medical Analysis, Medical Laboratory Technique College, the Islamic University, Najaf, Iraq.
Mohammed Jawad AlnajarDepartment of Pharmacy, Al-Nisour University College, Nisour Seq. Karkh, Baghdad, Iraq.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune disorders, where the immune response targets self-tissues, causing chronic inflammation and damage to the tissue, afflict millions of individuals around the globe. Besides their traditional role in hemostasis, platelets have emerged as immune regulators by releasing non-coding RNAs (ncRNAs), gene-regulatory molecules without protein-coding capacity. In this review, the role of platelet-derived ncRNAs in the immunopathogenesis of autoimmune disease as possible diagnostic and therapeutic markers will be elucidated. The role of non-coding RNAs (lncRNAs) and ncRNA-derived extracellular vesicles (EVs) obtained from platelets in the immunopathogenesis of autoimmune diseases will be clarified. Platelet-derived H19 (lncRNA) has been shown to participate in the immunopathogenesis of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) by influencing inflammation through affecting systemic immune responses; however, the obstacle to detecting and characterizing ncRNAs and their released factors remains challenging due to their small size and intricate regulation; next-generation sequencing and sensitive biosensors have emerged as potential solutions for such matters. This review highlights the role of platelet-derived ncRNAs as well as their exosomal cargos in autoimmune diseases, opening new horizons in diagnostic and therapeutic approaches for autoimmune diseases. Relevant literature was systematically searched in PubMed and Scopus databases using the keywords "platelet-derived ncRNAs," "autoimmunity," and "autoimmune diseases," all less than 10 years old.

Indexed as

Autoimmune DiseasesBlood PlateletsInflammationRNA, UntranslatedAnimalsHumansRNA, UntranslatedAutoimmune diseasesEVsImmunopathogenesisNcRNAsPlatelets

Identifiers

PMID41511537

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.