ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2026
Moving beyond global scores: the added value of clinical dimensions for assessing HRQoL in mental disorders.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Abstract
purposeHealth-Related Quality of Life (HRQoL) is an important outcome in health services research, but the suitability of generic HRQoL instrument for mental health populations is debated. This study investigates how clinical mental health dimensions (Norse Feedback, NF) supplement the generic HRQoL instruments (EuroQol five-dimensions five-level, EQ-5D-5 L) to explain their subjective well-being, defined by self-rated health (EuroQol Visual Analogue Scale, EQ-VAS) and life satisfaction.
methodsIn a cross-sectional study, 307 adults in specialized mental health treatment in Norway completed the EQ-5D-5 L and the modified NF. We compared a baseline regression model using only EQ-5D-5 L dimensions with a comprehensive model using factors derived from an Exploratory Factor Analysis of all 33 combined dimensions: 5 from EQ-5D-5 L and 28 from NF.
resultsFactor analysis yielded five factors, two of which ('Behavioral problems/externalizing' and 'Social/life stability') consisted exclusively of clinical dimensions not captured by the EQ-5D-5L. A comprehensive model using these factor scores significantly improved explanatory power over a baseline EQ-5D-5L model. The adjusted R² increased by 8.4% points for EQ-VAS (from 23.5 to 31.9%) and by 17.3% points for life satisfaction (from 41.1% to 58.4%). The dominant 'Psychological distress' factor was key to this improvement, integrating the single EQ-5D-5L 'Anxiety/depression' dimension with eleven clinical dimensions like Internal avoidance and Hopelessness.
conclusionWhile the EQ-5D-5 L is valuable, its assessment of well-being in this population is significantly enhanced by incorporating some clinical dimensions. Particularly, mental health-specific dimensions such as Internal avoidance, Intrusive memories, Self-contempt and Hopelessness played crucial roles to understand the gap between generic HRQoL and their sense of overall well-being.
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