SynthesisEuropean respiratory review : an official journal of the European Respiratory Society2025
The risk of cardiovascular, cerebrovascular and thromboembolic events after community-acquired pneumonia among adults: a systematic literature review.
Synthesis in European respiratory review : an official journal of the European Respiratory Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Risk of Cardiorespiratory Events Following Respiratory Syncytial Virus-Related Hospitalization.JAMA network open · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCommunity-acquired pneumonia (CAP) may prompt long-term complications. We reviewed the absolute and relative risks of cardiac/vascular events after pneumococcal (PCAP) and all-cause CAP (aCAP) in adults.
methodsWe searched Embase and PubMed for publications from high-income countries between 2000 and 2021, comparing the relative risk of cardiac/vascular events after CAP in adults to those without CAP. We also reviewed event risks among patients with CAP. In this review, CAP has been used as an umbrella term, including both PCAP and aCAP.
resultsWe included 19 of 6917 identified publications. CAP was independently associated with cardiovascular disease (CVD), including heart failure and acute coronary syndrome, as well as deep-vein thrombosis and pulmonary embolism. The relative risk for cardiac/vascular events in the year post-CAP ranged from 1.4 to 4.1 compared to non-CAP patients. The highest risk occurred immediately after the CAP episode, but the risk remained elevated for years. The risk for CVD <1 year post-CAP was 4.6% in individuals aged 45-64 years and 17.9% for those aged 65+ years. The cumulative risk of cardiac/vascular events after CAP increased with time of follow-up and comorbidities.
conclusionsCardiac/vascular events occur frequently after CAP and the association persists beyond the acute phase of infection. Public health evaluations of interventions for the prevention of CAP should consider these long-term sequelae.
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