Evidence map›Paper›PMID 41511351›Full record

ArticleCells2025

Proteasomal Degradation of Mutant Huntingtin Exon1 Regulates Autophagy.

Austin Folger, Chuan Chen, Phasin Gonzalez, Sophia L Owutey, Yanchang Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Long-term artificial sweetener exposure increases the risk of atherosclerosis.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Austin FolgerDepartment of Biomedical Sciences, College of Medicine, Florida State University, 1115 West Call Street, Tallahassee, FL 32306-4300, USA.
Chuan ChenCollege of Biological Sciences, Hebei University, Baoding 071002, China.
Phasin GonzalezCollege of Medicine, Florida State University, 1115 West Call Street, Tallahassee, FL 32306-4300, USA.
Sophia L OwuteyDepartment of Biomedical Sciences, College of Medicine, Florida State University, 1115 West Call Street, Tallahassee, FL 32306-4300, USA.ORCID 0009-0001-7028-4526
Yanchang WangDepartment of Biomedical Sciences, College of Medicine, Florida State University, 1115 West Call Street, Tallahassee, FL 32306-4300, USA.ORCID 0000-0001-6782-0570

Funding

Temporal-spatial control of mitotic regulators by polySUMOylationR01GM151447 · NIGMS · FLORIDA STATE UNIVERSITY · PI Yanchang Wang · 2023 to 2026
$1.4M
NIGMS NIH HHS R01 GM151447NIGMS NIH HHS R01GM151447
6 · The paper itself

Abstract

Accumulation of misfolded proteins is implicated in neurodegenerative diseases. One of these is Huntington's disease, which is caused by an expansion of trinucleotide (CAG) repeats in exon 1 of huntingtin gene (

Indexed as

AutophagyExonsHuntingtin ProteinMutationProteasome Endopeptidase ComplexCell Cycle ProteinsHumansProteolysisSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsUbiquitinationValosin Containing ProteinCell Cycle ProteinsHTT protein, humanHuntingtin ProteinProteasome Endopeptidase ComplexSaccharomyces cerevisiae ProteinsValosin Containing ProteinautophagyCdc48 complexIBophagymisfolded proteinsmutant huntingtin exon1 (mHttEx1)proteasome

Identifiers

PMID41511351
PMCPMC12785617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.