Evidence map›Paper›PMID 41511350›Full record

ArticleCells2025

Multiomic Analyses Reveal Brainstem Metabolic Changes in a Mouse Model of Dravet Syndrome.

Ashwini Sri Hari, Alexandria M Chan, Audrey Scholl, Aidan Mulligan, Janint Camacho, Ireland Rose Kearns, Gustavo Vasquez Opazo, Jenna Cheminant, Teresa Musci, Min-Jee Goh and 4 more

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ashwini Sri HariEpilepsy Therapy Screening Program (ETSP) Contract Site, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-8019-2123
Alexandria M ChanDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0001-6196-3036
Audrey SchollDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA.
Aidan MulliganDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA.
Janint CamachoEpilepsy Therapy Screening Program (ETSP) Contract Site, University of Utah, Salt Lake City, UT 84112, USA.
Ireland Rose KearnsEpilepsy Therapy Screening Program (ETSP) Contract Site, University of Utah, Salt Lake City, UT 84112, USA.
Gustavo Vasquez OpazoEpilepsy Therapy Screening Program (ETSP) Contract Site, University of Utah, Salt Lake City, UT 84112, USA.
Jenna CheminantDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA.
Teresa MusciDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA.
Min-Jee GohDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA.
Alessandro VenosaDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0003-3741-2634
Philip J MoosDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-8223-442X
Martin GolkowskiDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-0996-1655
Cameron S MetcalfEpilepsy Therapy Screening Program (ETSP) Contract Site, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-1510-0405

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
Integrated mass spectrometry-based chemoproteomic and genomic technologies for studying dynamic kinase interactomesR35GM150766 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Martin Golkowski · 2023 to 2026
$1.5M
CTSA Postdoctoral T32 at University of Utah: Spheres of Translation Across the Research Spectrum (STARS) Training ProgramT32TR004394 · NCATS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ANGELA FAGERLIN, Keke Celeste Fairfax · 2023 to 2026
$1.1M
Agilent 6550 QTOF system for U of UtahS10OD016232 · OD · UNIVERSITY OF UTAH · PI COX, JAMES ERIC · 2013 to 2013
$578k
Q-ToF Mass Spectrometer for the University of Utah MS and Proteomics CoreS10OD018210 · OD · UNIVERSITY OF UTAH · PI COX, JAMES ERIC · 2015 to 2015
$530k
Agilent 7200 GC/Q-TOF for the University of UtahS10OD021505 · OD · UNIVERSITY OF UTAH · PI COX, JAMES ERIC · 2016 to 2016
$401k
Dravet Syndrome Foundation 000000000000000NCATS NIH HHS T32 TR004394NCI NIH HHS P30 CA042014NIGMS NIH HHS R35 GM150766NIH HHS S10 OD016232NIH HHS S10 OD018210NIH HHS S10 OD021505
6 · The paper itself

Abstract

Dravet Syndrome (DS) is a severe genetic epileptic encephalopathy caused by mutations in the

Indexed as

Brain StemEpilepsies, MyoclonicAnimalsDisease Models, AnimalMetabolomeMiceMultiomicsNAV1.1 Voltage-Gated Sodium ChannelProteomicsNAV1.1 Voltage-Gated Sodium ChannelbrainstemDravet Syndromemetabolismsudden unexpected death in epilepsy (SUDEP)

Identifiers

PMID41511350
PMCPMC12785442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.