Evidence map›Paper›PMID 41511349›Full record

ArticleCells2025

Microglial Expression of Serotonin Receptors Reveals Parallel Regulation of 5-HT2b and BDNF in the Rat Hippocampus.

Andrei Turkin, Maria Sidorova, Ekaterina Kurilova, Natalia Alenina, Oksana Tuchina, Friederike Klempin

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andrei TurkinInstitute of Medicine and Life Sciences (MEDBIO), Immanuel Kant Baltic Federal University, Kaliningrad 236035, Russia.ORCID 0000-0003-0175-3293
Maria SidorovaInstitute of Medicine and Life Sciences (MEDBIO), Immanuel Kant Baltic Federal University, Kaliningrad 236035, Russia.
Ekaterina KurilovaInstitute of Medicine and Life Sciences (MEDBIO), Immanuel Kant Baltic Federal University, Kaliningrad 236035, Russia.
Natalia AleninaMax Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.ORCID 0000-0002-6071-5433
Oksana TuchinaInstitute of Medicine and Life Sciences (MEDBIO), Immanuel Kant Baltic Federal University, Kaliningrad 236035, Russia.ORCID 0000-0003-1480-1311
Friederike KlempinMax Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.ORCID 0000-0003-3171-0497

Funding

This work was supported by the Russian Foundation for Basic Research (RFBR) grant 20-015-00470 to A.T., M.S., E.K., and O.T., E.K. also received funding from the Russian Federal Academic Leadership Program «Priority 2030» from IKBFU (project number 123110 grant 20-015-00470; project number 123110800174-4;
6 · The paper itself

Abstract

Growing evidence suggests that psychiatric disorders are characterized by a prolonged inflammatory state, which may influence the efficacy of compounds targeting serotonin. Serotonin is a key signaling molecule in neuroplasticity of the adult hippocampus and involved in antidepressant action. Recent in vitro studies indicate the neurotransmitter may also facilitate the response to inflammation and potentially modulate microglial function towards neuroprotection. Using

Indexed as

Brain-Derived Neurotrophic FactorHippocampusMicrogliaReceptor, Serotonin, 5-HT2BReceptors, SerotoninAnimalsGene Expression RegulationMaleRatsSerotoninTryptophan HydroxylaseBrain-Derived Neurotrophic FactorReceptor, Serotonin, 5-HT2BReceptors, SerotoninSerotoninTryptophan Hydroxylase5-HT2bBDNFinflammationmicrogliaserotoninTph2

Identifiers

PMID41511349
PMCPMC12785902

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.