ReviewCells2025
S1PR2 Signaling in the Lung: Understanding Its Role in Health and Disease.
Review in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- M1 macrophage-derived exosomes aggravate diabetic nephropathy by regulating the WTAP/S1PR2 axis.Journal of diabetes investigation · 2026Article
- Extracellular Vesicles as Drivers of Lung Endothelial Dysfunction in ARDS: Mechanisms and Therapeutic Opportunities.Comprehensive Physiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Sphingosine-1-phosphate receptors (S1PRs) are a family of G protein-coupled transmembrane proteins that play essential roles across nearly all organ systems, including the regulation of pulmonary physiology and immune responses. Expressed across diverse lung cell types, S1PRs mediate critical biological processes such as vascular barrier integrity, immune cell trafficking, and inflammation. While the signaling pathways and physiological functions of S1PR1 and S1PR3 have been extensively characterized, the role of S1PR2 remains less clearly defined and context-dependent. In this review, we summarize current knowledge on S1PR2 signaling within major pulmonary cell populations and explore its contribution to lung homeostasis and disease. By synthesizing evidence from molecular, cellular and in vivo studies, this review aims to summarize the current understanding of S1PR2 signaling across major pulmonary cell populations and its roles in lung homeostasis and disease. The findings of this study could help develop new strategies for treating pulmonary disorders and other diseases by targeting S1PR2.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.