Evidence map›Paper›PMID 41511084›Full record

ReviewJournal of virology2026

Metabolic hijackers: how viral proteins redefine host cell landscapes.

Adam Hafner, Rebekah L Mokry, John G Purdy, Christiane E Wobus

Abstract readReview
In one paragraph

Review in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Adam HafnerDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Rebekah L MokryDepartment of Immunobiology, University of Arizona, Tucson, Arizona, USA.ORCID 0000-0002-8882-4332
John G PurdyDepartment of Immunobiology, University of Arizona, Tucson, Arizona, USA.ORCID 0000-0001-7460-7567
Christiane E WobusDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0001-5286-0924

Funding

Impact of diverse nutrient environment on viral replication and metabolite flow in human cytomegalovirus infectionF32AI178919 · NIAID · UNIVERSITY OF ARIZONA · PI MOKRY, REBEKAH L · 2023 to 2024
$143k
National Institute of Allergy and Infectious Diseases 5T32AI007528National Institute of Allergy and Infectious Diseases F32AI178919National Institute of Allergy and Infectious Diseases R01AI155539National Institute of Allergy and Infectious Diseases R01AI162671NIAID NIH HHS F32 AI178919
6 · The paper itself

Abstract

Viruses are metabolic engineers of host cells. As obligate intracellular pathogens, they rely on host cell metabolism for efficient viral replication. The manipulation of host metabolic processes is a strategy shared among diverse virus families to secure the necessary resources for replicating new genomes, building more virus particles, and supporting cell growth and proliferation. Key metabolic pathways targeted by viruses for disruption and manipulation are glycolysis, glutaminolysis, and lipid metabolism. However, the mechanisms behind virus-induced metabolic reprogramming and the viral proteins mediating it remain poorly understood. This review explores how specific viral proteins reshape the metabolic milieu of host cells during viral infections. We also highlight common themes and outline gaps in knowledge to stimulate further investigations into how viral proteins manipulate host metabolism. Such mechanistic insights will deepen our understanding of virus-host interactions and may reveal novel therapeutic targets.

Indexed as

Host-Pathogen InteractionsViral ProteinsVirus DiseasesVirusesAnimalsGlycolysisHumansLipid MetabolismMetabolic ReprogrammingVirus ReplicationViral Proteinscellular metabolismglutaminolysisglycolysislipid metabolismRNA and DNA virus proteins

Identifiers

PMID41511084
PMCPMC12911867

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.