Evidence map›Paper›PMID 41511055›Full record

ReviewACS chemical biology2026

Chemical Strategies for Controlling Sulfation in Biomacromolecules.

Chao Liu, Xueyi Liu, Yu Deng, Jia Niu

Abstract readReview
In one paragraph

Review in ACS chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chao LiuDepartment of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.
Xueyi LiuDepartment of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.
Yu DengDepartment of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.
Jia NiuDepartment of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.ORCID 0000-0002-5622-6362

Funding

Development of Compact CRISPR Editors for Multiplexed Editing of Complex Gene NetworksDP2HG011027 · NHGRI · BOSTON COLLEGE · PI NIU, JIA · 2019 to 2020
$2.5M
Chemical Synthesis of Biologically Significant Polysaccharides via LivingPolymerizationR01GM160917 · NIGMS · BOSTON COLLEGE · PI NIU, JIA · 2025 to 2025
$326k
NHGRI NIH HHS DP2 HG011027NIGMS NIH HHS R01 GM160917
6 · The paper itself

Abstract

Sulfation is a fundamental post-translational modification that imparts negative charge and structural complexity to biomolecules, thereby regulating molecular recognition, signaling, and homeostasis across all domains of life. Yet, the ability to interrogate the biological functions of sulfation has long been hindered by the difficulty of constructing molecules with defined sulfation patterns. This Account summarizes our efforts to develop chemical strategies that enable precise control over sulfation in glycans and proteins. We describe an organobase-promoted sulfur(VI) fluoride exchange (SuFEx) chemistry that allows early stage, chemoselective

Indexed as

PolysaccharidesProteinsSulfatesHeparan SulfateProtein Processing, Post-TranslationalHeparan SulfatePolysaccharidesProteinsSulfates

Identifiers

PMID41511055
PMCPMC12917767

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.