Trial reportClinical and experimental dental research2026
Dexketoprofen Time-Dependent Administration After Third Molar Extraction: A Pilot Randomized Cross-Over Controlled Trial.
Trial report in Clinical and experimental dental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05176158 (Efficacy of Dexketoprofen Prescribed According to the Circadian Rhythms), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Dexketoprofen Prescribed According to the Circadian Rhythms
Who cites it
2 citing papers in PubMed.
- Effect of NSAIDs, melatonin, vitamin D and vitamin B12 chronotherapy on postoperative recovery after third molar surgical extraction: A pilot randomized crossover placebo-controlled trial.Oral and maxillofacial surgery · 2026Trial
- Impact of NSAIDs on post-operative bleeding in minor dental and oral surgery: A clinical study.Bioinformation · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectiveTo assess how chronotherapy influences recovery after bilateral third molar extraction when Dexketoprofen is administered as an anti-inflammatory agent. MATERIAL AND
methodsA randomized cross-over controlled trial with 10 patients with bilateral impacted third molar extraction was enrolled. For 7 days after the surgery, the chronotherapy group was prescribed one dose of Dexketoprofen (25 mg) limited to daytime, while the control group were given two doses per day (every 12 h). Pain intensity was recorded at baseline, 24, 48, and 72 h, while facial swelling parameters were evaluated at baseline, 24, 72, and 168 h (Day 7) postoperatively. Also, the inflammatory profile was analyzed for each patient by blood samples at baseline, 72 and 168 h. The concentrations of IL-1β, IL-1a, IL-2, IL-4, IL-6, IL-7, IL-10, and IL-13 were measured using high-sensitivity multiplex map human immunoassays.
resultsNo significant differences in postoperative VAS pain, swelling, and mouth opening (trismus) measures were observed between the two groups. However, the chronotherapy group had reduced overall postoperative complications compared to the control group. Regarding postoperative recovery, pain intensity scores in the chronotherapy group at 24, 48, and 72 h indicated a faster recovery than the control group. Blood samples analysis showed no statistical differences between the different inflammatory markers studied at 72 h or Day 7 in both groups.
conclusionsDaytime administration of NSAIDs might be sufficient to manage postoperative pain after third molar extraction, and complications were similar between both groups. CLINICAL
trial registrationclinicaltrials. gov, Identifier database: NCT05176158.
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