Trial reportClinical and experimental dental research2026
Clinical Assessment of the Effect of Hypericum perforatum Chewing Gum on Salivary Streptococcus mutans Count, pH, Plaque Index, and Gingival Bleeding: A Randomized Clinical Trial.
Trial report in Clinical and experimental dental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Clinical Assessment of the Effect of Hypericum perforatum Chewing Gum on Salivary Streptococcus mutans Count, pH, Plaque Index, and Gingival Bleeding: A Randomized Clinical Trial.Clinical and experimental dental research · 2026Trial
- In Vitro Efficacy of Ultrasonic Debridement with Adjunctive St. John's Wort on Multispecies Dental Biofilms.Medicina (Kaunas, Lithuania) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectivesHypericum perforatum L. offers several beneficial effects, for example antioxidant, antitumor, wound healing. Our aim was to ascertain the effect of H. perforatum extract gum on salivary Streptococcus mutans count, pH, plaque index, and gingival bleeding. MATERIALS AND
methodsA total of 54 participants were assigned into two groups of gum with or without herbal extract. Unstimulated saliva was collected to assess Streptococcus mutans and pH.
resultsStatistically significant differences in plaque index were observed between before and after use of gum in both groups (p < 0.01). There was a significant difference in plaque index after applying H. perforatum gum compared to placebo (p < 0.01). Statistically significant differences in gum bleeding between before and after use of herbal gum were observed (p < 0.01), but no significant difference was observed in gum bleeding between before and after gum use in placebo group (p = 0.24). A significant difference was observed in gum bleeding between herbal and placebo groups (p < 0.01). There was significant difference in Streptococcus mutans count between before and after gum use in both groups in two measurements (p < 0.01). Further, there was a significant difference in Streptococcus mutans count between herbal gum and placebo groups in two measurements (p < 0.01). Significant differences were observed in salivary pH between before and after consuming gum in herbal gum and placebo groups (p < 0.01 and p = 0.003, respectively). No significant difference in salivary pH was observed between two groups (p = 0.07).
conclusionsOur results revealed gum formulation of H. perforatum extract had significant effects on lowering salivary Streptococci mutans count, plaque index, and gingival bleeding compared to gum without extract group as well as their amounts before gum use. Although both gums elevated salivary pH, there was no statistically significant difference in short-term measurements. Under the conditions of this study, H. perforatum gum can be considered a promising adjutant for oral health improvement.
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Registered trials
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