Evidence map›Paper›PMID 41510670›Full record

ArticleNeuropsychopharmacology reports2026

Disruption of the l-DOPA Receptor Gpr143/OA1-Gene in Mice Creates a Unique Mixed Psychosis-Like Phenotype.

Yoshio Goshima, Haruko Nakamura, Motokazu Koga, Junka Koyama, Yayoi Kimura, Maya N Vasishth, Evan Y Snyder, Masashi Asai, Kenta Sakai, Daiki Masukawa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yoshio GoshimaDepartment of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Haruko NakamuraDepartment of Neurology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Motokazu KogaDepartment of Anesthesiology, Kanagawa Cancer Center, Yokohama, Japan.
Junka KoyamaDepartment of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Yayoi KimuraAdvanced Medical Research Center, Yokohama City University, Yokohama, Japan.ORCID https://orcid.org/0000-0002-4612-4602
Maya N VasishthSanford Burnham Prebys (SBP) Medical Discovery Institute, La Jolla, California, USA.
Evan Y SnyderSanford Burnham Prebys (SBP) Medical Discovery Institute, La Jolla, California, USA.
Masashi AsaiDepartment of Kampo Pharmacy, Yokohama University of Pharmacy, Yokohama, Japan.ORCID https://orcid.org/0000-0001-6392-0910
Kenta SakaiEnvironmental Health and Prevention Research Unit, Yokohama University of Pharmacy, Yokohama, Japan.
Daiki MasukawaDepartment of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Funding

Japan Agency for Medical Research and Development JP22ek0109431Japanese SRF Grant for Biomedical Research 1516Japanese SRF Grant for Biomedical Research 2021G010Japanese SRF Grant for Biomedical Research 2021T001JPMH KAKENHI 22KC1005Merkin FoundationMinistry of Education, Culture, Sports, Science and Technology 20K07069Ministry of Education, Culture, Sports, Science and Technology 21H02673Ministry of Education, Culture, Sports, Science and Technology 42890001Takeda Science FoundationUehara Memorial Foundation 201810115
6 · The paper itself

Abstract

GPR143, originally identified as the gene product of ocular albinism 1 (OA1), a G protein-coupled receptor (GPCR), can function as a receptor for l-3,4-dihydroxyphenylalanine (DOPA), a precursor of dopamine (DA). To examine the physiological and pathophysiological roles of GPR143, we analyzed the behavior of Gpr143 gene-deficient (Gpr143

Indexed as

Membrane GlycoproteinsPsychotic DisordersReceptors, G-Protein-CoupledReceptors, NeurotransmitterAnimalsBehavior, AnimalDisease Models, AnimalEye ProteinsMesolimbic SystemMiceMice, KnockoutMicroarray AnalysisPhenotypePrepulse InhibitionProsencephalonEye ProteinsGpr143 protein, mouselevodopa receptorMembrane GlycoproteinsReceptors, G-Protein-CoupledReceptors, NeurotransmitterbehaviorGPR143l‐DOPAocular albinism 1schizophrenia

Identifiers

PMID41510670
PMCPMC12784213

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.