Evidence map›Paper›PMID 41510641›Full record

ArticleFEBS letters2026

Sequence determinants of RNA G-quadruplex unfolding by Arg-rich regions.

Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui-Ting Lee and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Naiduwadura Ivon Upekala De SilvaDepartment of Chemistry, University of Alabama at Birmingham, AL, USA.
Puspa KunwarDepartment of Chemistry, University of Alabama at Birmingham, AL, USA.
Md Ibnul Rifat RahmanDepartment of Chemistry, University of Alabama at Birmingham, AL, USA.
Joanna Koryo KwaoDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, SC, USA.
Nathan LehmanDepartment of Chemistry, University of Alabama at Birmingham, AL, USA.
Zihan ZhangDepartment of Chemistry, University of Alabama at Birmingham, AL, USA.
Trenton PaulDepartment of Chemistry, University of Alabama at Birmingham, AL, USA.
Claire ChengLivingston High School, NJ, USA.
Nicholas TruexDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, SC, USA.
Hui-Ting LeeDepartment of Chemistry, University of Alabama at Birmingham, AL, USA.
Jun ZhangDepartment of Chemistry, University of Alabama at Birmingham, AL, USA.ORCID https://orcid.org/0000-0002-5842-7424

Funding

Targeting NMDA Receptors and Brain Estradiol to Rescue Memory in Aging FemalesP20GM109091 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI RONINSON, IGOR B · 2014 to 2024
$25.2M
The central roles of SRSF1 in early-stage spliceosome assemblyR35GM147091 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Jun Zhang · 2022 to 2026
$2.0M
National Institute of Health P20GM109091National Institute of Health R35GM147091National Science Foundation Graduate Research Fellowship MCB 2338902NIGMS NIH HHS P20 GM109091NIGMS NIH HHS R35 GM147091
6 · The paper itself

Abstract

RNA sequences with the potential to form G-quadruplexes (rGQs) are widespread but largely unfolded in cells by unknown mechanisms. rGQ folding status is a critical regulator of RNA splicing and translation. We show that rGQs can be unfolded by SR proteins, SR-related proteins, and other Arg-rich proteins, including SRSF1, SRSF3, SRSF9, U1-70K, and U2AF1. The length and composition of Arg-rich regions are key determinants of this activity: Arg residues are the primary drivers, while acidic residues attenuate the unfolding activity. To unfold ARPC2 rGQ, at least 13 Arg residues are required. Our findings identify Arg-rich proteins as previously unrecognized, helicase-independent regulators of rGQ structures, with potential broad impacts on RNA processing that merit further investigation.

Indexed as

ArginineG-QuadruplexesRNAHumansRNA SplicingSerine-Arginine Splicing FactorsArginineRNASerine-Arginine Splicing FactorsArg‐rich peptidesG‐quadruplexsplicingSR proteinsSR‐related proteinsunfolding

Identifiers

PMID41510641
PMCPMC12909071

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.