ArticleLab on a chip2026
Affordable, cleanroom-free millifluidic production of targeted lipid nanocarriers
Callum D Hay, Suchaya M Mahutanattan, Colin P Pilkington, Miguel Paez-Perez, Kimberly A Kelly, Yuval Elani, Marina K Kuimova, Nicholas J Brooks, Michela Noseda, James W Hindley and 1 more
Abstract read
In one paragraphArticle in Lab on a chip, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Callum D HayDepartment of Chemistry, Molecular Science Research Hub, Imperial College London, 82 Wood Lane, London, W12 0BZ, UK. j.hindley14@imperial.ac.uk.
Suchaya M MahutanattanDepartment of Chemistry, Molecular Science Research Hub, Imperial College London, 82 Wood Lane, London, W12 0BZ, UK. j.hindley14@imperial.ac.uk.
Colin P PilkingtonDepartment of Chemistry, Molecular Science Research Hub, Imperial College London, 82 Wood Lane, London, W12 0BZ, UK. j.hindley14@imperial.ac.uk.ORCID 0000-0002-3113-7611 Miguel Paez-PerezDepartment of Chemistry, Molecular Science Research Hub, Imperial College London, 82 Wood Lane, London, W12 0BZ, UK. j.hindley14@imperial.ac.uk.ORCID 0000-0003-3933-8722 Kimberly A KellyDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, 22908, USA.
Yuval ElaniInstitute of Chemical Biology, Imperial College London, Molecular Sciences Research Hub, London, W12 0BZ, UK.ORCID 0000-0002-9603-2490 Marina K KuimovaDepartment of Chemistry, Molecular Science Research Hub, Imperial College London, 82 Wood Lane, London, W12 0BZ, UK. j.hindley14@imperial.ac.uk.ORCID 0000-0003-2383-6014 Nicholas J BrooksDepartment of Chemistry, Molecular Science Research Hub, Imperial College London, 82 Wood Lane, London, W12 0BZ, UK. j.hindley14@imperial.ac.uk.
Michela NosedaImperial Centre for Translation and Experimental Medicine, Imperial College London, Hammersmith Campus, London, SW7 2AZ, UK.
James W HindleyDepartment of Chemistry, Molecular Science Research Hub, Imperial College London, 82 Wood Lane, London, W12 0BZ, UK. j.hindley14@imperial.ac.uk.ORCID 0000-0002-3392-4387 Oscar CesDepartment of Chemistry, Molecular Science Research Hub, Imperial College London, 82 Wood Lane, London, W12 0BZ, UK. j.hindley14@imperial.ac.uk.ORCID 0000-0002-6418-5644 Funding
BBSRC-funded 21ENGBIO BB/W012871/1BHF-funded grants RG/15/1/31165BHF-funded grants SP/19/1/34461British Heart Foundation EP/S023518/1
6 · The paper itselfAbstract
Lipid nanocarriers utilise the self-assembly of amphiphilic molecules to generate particle formulations capable of drug encapsulation and dynamic interactions with user-defined cell types, enabling applications within targeted therapeutic delivery. This offers increased bioavailability, stability, and reduced off-target effects, with the promise of application to numerous cell types and consequently, diseases. Here, we have developed a highly accessible, cleanroom-free method for the fabrication of poly(methyl methacrylate) millifluidic vertical flow focusing (VFF) devices
Indexed as
Drug CarriersLipidsMicrofluidic Analytical TechniquesNanoparticlesAnimalsCell LineCell SurvivalMyocytes, CardiacPolymethyl MethacrylateVitamin K 3Drug CarriersLipidsPolymethyl MethacrylateVitamin K 3
Identifiers
PMID41510603
PMCPMC12784244
What OpenQuestion holds
Textmetadata
LicenceCC BY
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