ArticleMethodology : European journal of research methods for the behavioral & social sciences2025
A Practical Guide to Conducting Dose-Response Meta-Analyses in Epidemiology.
Article in Methodology : European journal of research methods for the behavioral & social sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prognostic significance of stress hyperglycemia ratio in patients undergoing percutaneous coronary intervention: a dose-response meta-analysis.BMJ open diabetes research & care · 2026Pooled it
- Association between adherence to the Mediterranean Diet and pancreatic cancer risk: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- A Practical Guide to Conducting Dose-Response Meta-Analyses in Epidemiology.Methodology : European journal of research methods for the behavioral & social sciences · 2025Article
- Interpreting heterogeneity and effect size in meta-analysis of Suzetrigine for acute pain.Saudi journal of anaesthesiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Dose-response relationships between continuous risk factors and disease outcomes are necessary for understanding the risks related to different levels of exposure. Dose-response risk curves can lead to more targeted public health messaging, prevention efforts, and policy implementation. Meta-analyses are often used to combine statistical results from different studies and can be used to model dose-response relationships. However, several challenges are encountered when performing dose-response meta-analysis, such as having heterogeneous reference categories, inconsistent measures of risk, and determining the most accurate shape of the curve. In this paper, we propose a three-step process for estimating dose-response relationships via meta-analysis, which involves: 1) harmonizing the measures of risk, 2) homogenizing the reference category, and 3) selecting meta-regression models. We use data obtained from a systematic review on the dose-response relationship between alcohol consumption and the risk of chronic liver disease to provide an example of the proposed process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.