ArticleCureus2025
Genetics of High-Grade Endometrioid Adenocarcinoma of the Ovary With Yolk Sac Differentiation: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Yolk sac tumors (YST) are relatively rare ovarian neoplasms that typically occur in young women, whereas yolk sac differentiation in ovarian epithelial tumors represents an exceedingly rare malignancy of perimenopausal and postmenopausal women. The latter is usually associated with Müllerian epithelial neoplasms and is somatically derived. Accurate identification of tumor lineage is essential for proper classification and treatment, especially in mixed tumors with overlapping morphological and immunohistochemical features and shared mutations. Most of the reported cases have lacked genetic testing. Here, we present a case of high-grade endometrioid adenocarcinoma with yolk sac tumor differentiation in a perimenopausal woman. The tumor demonstrated an unusual morphology and immunohistochemical profile, raising the possibility of either a common early precursor or divergent differentiation. Genomic analysis revealed pathogenic mutations in
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