ArticleTranslational lung cancer research2025
Additional 1.1-mm cryobiopsy trial guided by rapid on-site cytologic evaluation of touch imprint cytology result of small forceps biopsy in peripheral pulmonary lesions: a prospective single-center study.
Article in Translational lung cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- A modified cryobiopsy specimen retrieval method using a thin bronchoscope and small guide sheath for the diagnosis of peripheral pulmonary lesions.Translational lung cancer research · 2026Article
- Diagnosis of Synchronous Primary Lung Cancers Using EBUS-TBNA and BDBD-Assisted Transbronchial Biopsy During a Single Bronchoscopic Procedure: A Case Report.Respirology case reports · 2026Article
- Feasibility of direct cryobiopsy specimen retrieval through the working channel of an ultrathin bronchoscope-a retrospective study of single institute.Journal of thoracic disease · 2026Article
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17 authors.
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Abstract
Background: Ultrathin cryobiopsy (CB) using a 1.1-mm cryoprobe has been shown to improve the diagnostic yield of bronchoscopy for peripheral pulmonary lesions (PPLs). However, CB may not be actively adopted in some institutions because of concerns about bleeding and pneumothorax. Each facility needs to develop its own strategies to perform CB selectively and safely. Rapid on-site cytologic evaluation of touch imprint cytology (ROSE-TIC) of small (1.5 mm) forceps biopsy (FB) may help guide the selective application of CB. This study aimed to evaluate the safety and efficacy of adding CB in patients with ROSE-TIC-negative FB. Methods: Patients with PPLs <30 mm were enrolled in this single-center prospective study. First, they underwent bronchoscopic biopsy with a 1.5-mm FB and ROSE-TIC. CB using a 1.1-mm cryoprobe was added only when the ROSE-TIC of the FB was negative. Safety outcomes (especially bleeding) and diagnostic yields were compared solely between ROSE-TIC-positive and ROSE-TIC-negative groups. In addition, the diagnostic yield of FB results, regardless of ROSE-TIC positivity or negativity, was evaluated. The specimen sizes and ROSE-TIC accuracies were also assessed. Results: From November 2023 to March 2025, 50 patients underwent bronchoscopic examinations according to the intended protocol. Grade ≥3 bleeding events did not occur, and Grade 1-2 bleeding was not significantly different between the ROSE-TIC-positive and ROSE-TIC-negative groups (P=0.35). The specific diagnostic yield of the ROSE-TIC-positive group was 87.5%, and that of the ROSE-TIC-negative group was 73.l%. In the ROSE-TIC-negative group, the FB-only results made a specific diagnosis in 34.6% [95% confidence interval (CI): 17.2-55.7%] compared with combined CB in 73.1% (95% CI: 44.3-82.8%). The overall diagnostic yield of specific findings was significantly higher in the combined CB group than that in the FB group (80% Conclusions: The selective addition of a 1.1-mm CB based on ROSE-TIC results of FB is a safe, feasible, and effective strategy for improving the specific diagnostic yield. This approach may be particularly beneficial for small PPLs of ≤20 mm.
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