Evidence map›Paper›PMID 41510386›Full record

ArticleTranslational lung cancer research2025

A study protocol of a single-arm, prospective, open-label, non-controlled, phase II study of neoadjuvant BL-B01D1 combined with aumolertinib in resectable stage II-IIIB non-small cell lung cancer patients with

Yue Chen, Jiandong Mei, Ge Gao, Benxia Zhang, Yanying Li, Zhiyu Peng, Chuan Li, Fanyi Gan, Qiang Pu, Chengwu Liu and 3 more

Registry-linked trialAbstract read
In one paragraph

Article in Translational lung cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06951464 (A Phase II Study to Evaluate the Safety and Efficacy of Neoadjuvant Therapy With BL-B01D1 in Combination With Almonertinib Followed by Adjuvant Almonertinib in Patients With Epidermal Growth Factor Receptor Mutation Positive Stage II-IIIB Resectable Non-Small Cell Lung Cancer), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06951464 phase2recruitingnot on this map

A Phase II Study to Evaluate the Safety and Efficacy of Neoadjuvant Therapy With BL-B01D1 in Combination With Almonertinib Followed by Adjuvant Almonertinib in Patients With Epidermal Growth Factor Receptor Mutation Positive Stage II-IIIB Resectable Non-Small Cell Lung Cancer

TypeinterventionalSponsorSichuan UniversityRan2025 to 2029Enrolled40ConditionsNon-Small Cell Lung CancerArmsBL-B01D1, Almonertinib
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yue Chen *Clinical Trial Center, West China Hospital, Sichuan University, Chengdu, China.
Jiandong Mei *Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.
Ge GaoClinical Trial Center, West China Hospital, Sichuan University, Chengdu, China.
Benxia ZhangClinical Trial Center, West China Hospital, Sichuan University, Chengdu, China.
Yanying LiDivision of Thoracic Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Zhiyu PengDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.
Chuan LiDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.
Fanyi GanDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.
Qiang PuDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.
Chengwu LiuDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.
Wenjie YangCenter of Biostatistics, Design, Measurement and Evaluation (CBDME), West China Hospital, Sichuan University, Chengdu, China.
Lunxu LiuDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.
Yongsheng WangDivision of Thoracic Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Current neoadjuvant strategies for resectable epidermal growth factor receptor ( Methods: This phase II, open-label, non-controlled, single-arm, dose escalation and dose expansion study will recruit 40 stage II-IIIB resectable NSCLC patients with Discussion: This protocol describes the methodology of study in order to identify neoadjuvant therapy of BL-B01D1 and aumolertinib for resectable stage II-IIIB NSCLC with Trial Registration: Clinicaltrials.gov identifier: NCT06951464. Registered on April 23, 2025. Protocol version: version 2.0, May 06, 2025.

Indexed as

aumolertinibBL-B01D1Epidermal growth factor receptor (EGFR)neoadjuvantnon-small-cell lung cancer (NSCLC)

Identifiers

PMID41510386
PMCPMC12775699

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.