ArticleJournal of diabetes and metabolic disorders2026
Estimated glucose disposal rate and cardiovascular outcomes in overweight/obese adults: a nationwide cross-sectional study with prospective cohort follow-up.
Article in Journal of diabetes and metabolic disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Longitudinal changes and cumulative exposure of estimated glucose disposal rate and all-cause mortality in middle-aged and older Chinese adults.Scientific reports · 2026Article
- The predictive value of combined assessment of estimated glucose disposal rate and non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio for cardiovascular disease risk: a nationwide cohort study.Frontiers in medicine · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Overweight/obesity is a critical global health crisis associated with cardiovascular disease (CVD) and mortality. Insulin resistance (IR) is a key pathophysiological mediator, but non-invasive IR markers for large-scale studies are limited. While the estimated glucose disposal rate (eGDR) predicts CVD outcomes in diabetes, its role in overweight/obese adults remains unexplored. This study aimed to, first, investigate the cross-sectional association between eGDR-a validated surrogate of insulin resistance calculated from waist circumference, hypertension status, and glycated hemoglobin (HbA1c)-and the prevalence of CVD, and second, to examine the prospective association between eGDR and the risk of all-cause and CVD-specific mortality among adults with overweight/obesity. Methods: Using 1999-2020 NHANES data, we conducted a cross-sectional study ( Results: In cross-sectional analyses, lower eGDR correlated with higher CVD risk. Cohort analyses revealed inverse relationships between eGDR and all-cause mortality [Q4 vs. Q1: HR = 0.72 (0.56-0.94), Conclusion: Low levels of eGDR were related with the risk of CVD and mortality in adults with overweight/obesity. Supplementary Information: The online version contains supplementary material available at 10.1007/s40200-025-01835-x.
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