ArticleResearch square2025
Fitness After Stroke Trial (FAST): Protocol for a Preliminary Efficacy Study of Recumbent Stepper High-Intensity Interval Training.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05936008 (Investigating Exercise Prescription Parameters on Aerobic Fitness and Vascular Health After Stroke), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating Exercise Prescription Parameters on Aerobic Fitness and Vascular Health After Stroke: A Pilot Study
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Authors and funding
8 authors.
Funding
Abstract
Background: Cardiorespiratory fitness and vascular health are significantly impaired post-stroke. High-intensity interval training (HIIT) has emerged as a promising strategy to improve walking in people with chronic stroke, but broadly integrating HIIT into stroke recovery remains limited. One key barrier is the reliance on maximal exercise testing to prescribe HIIT, which is often not feasible in clinical settings. To address this gap, the Fitness After Stroke Trial (FAST) evaluates the preliminary efficacy of HIIT compared to moderate-intensity continuous training (MICT), using a validated submaximal exercise testing protocol to guide individualized exercise prescription in people post-stroke. Methods: FAST will enroll 50 individuals with chronic stroke into a double-blind, two-arm, parallel-group preliminary efficacy trial. Participants will be stratified by lower extremity motor function and randomized to HIIT or MICT. Exercise sessions will occur three times per week for four weeks using a total body recumbent stepper. The primary outcome is estimated peak oxygen consumption from the TBRS submaximal exercise test. Secondary outcomes include middle cerebral artery velocity at rest and during exercise, flow-mediated dilation and pulse wave velocity. Tertiary outcomes include walking speed and distance. Discussion: FAST represents one of the earliest double-blind randomized trials to directly compare HIIT and MICT on a recumbent stepper in people post-stroke, using a validated submaximal exercise testing protocol to individualize exercise intensity. This study will generate preliminary effect sizes for key physiological and functional outcomes obtained with this modality, providing the critical data needed to optimize dosing strategies and power a future definitive trial. Trial registration: NCT05936008. Registered 7 July 2023, Study Details | Fitness After Stroke Trial | ClinicalTrials.gov.
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