ArticleResearch square2025
Exposure to organochlorine compounds in relation to weight maintenance.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00390637 (Diet, Obesity and Genes), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Diet, Obesity and Genes
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Authors and funding
5 authors.
Funding
Abstract
backgroundThe purpose was to test the hypothesis that exposures to organochlorine compounds are associated with body weight increases in a dietary intervention study.
methodsIn the DioGenes trial, adults with obesity who had at first lost at least 8% of their body weight then completed at least 26 weeks on a specific diet. Concentrations of major organochlorine compounds were assessed in plasma samples obtained at study baseline.
resultsA total of 372 participants with complete data were examined for plasma concentrations of major organochlorine compounds. A doubling in total-PCB in plasma was associated with an increase in weight (in kg) at 26 weeks by 0.43 (0.04;0.83), independent of diet group and sex. Associations for most individual organochlorines were in the same direction, though mostly not statistically significant, especially after adjustment. However,
conclusionsElevated plasma concentrations of some organochlorine compounds were weakly associated with increased weight gain, although most individual associations did not reach statistical significance after adjustment for PFAS exposure. However, p,p'-DDE concentrations showed a clear association with lowered body weight. Overall, the halogenated pollutants examined are likely to contribute to the obesity pandemic.
trial registrationThe original RCT is with ClinicalTrials.gov number NCT00390637.
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