Evidence map›Paper›PMID 41510274›Full record

ArticleResearch square2025

Local Misalignment Scoring Reveals Spatially Uniform Chondrocyte Disorganization in a Wnt5a-C83S Knock-in Model of Robinow Syndrome.

Zhendong A Zhong, Megan N Michalski, Cassandra R Diegel, Cheryl Christie, Zachary Klamer, Nathan J Lanning, Brian B Haab, Stephanie Grainger, Bart O Williams

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhendong A ZhongDepartment of Cell Biology, Van Andel Institute, Grand Rapids, MI 49503, USA.
Megan N MichalskiDepartment of Cell Biology, Van Andel Institute, Grand Rapids, MI 49503, USA.
Cassandra R DiegelDepartment of Cell Biology, Van Andel Institute, Grand Rapids, MI 49503, USA.
Cheryl ChristieDepartment of Cell Biology, Van Andel Institute, Grand Rapids, MI 49503, USA.
Zachary KlamerDepartment of Cell Biology, Van Andel Institute, Grand Rapids, MI 49503, USA.
Nathan J LanningDepartment of Cell Biology, Van Andel Institute, Grand Rapids, MI 49503, USA.
Brian B HaabDepartment of Cell Biology, Van Andel Institute, Grand Rapids, MI 49503, USA.
Stephanie GraingerDepartment of Cell Biology, Van Andel Institute, Grand Rapids, MI 49503, USA.
Bart O WilliamsDepartment of Cell Biology, Van Andel Institute, Grand Rapids, MI 49503, USA.ORCID 0000-0002-5261-5301

Funding

Understanding WNT9A/FZD9 Trafficking and SignalingR35GM142779 · NIGMS · VAN ANDEL RESEARCH INSTITUTE · PI GRAINGER, STEPHANIE LAURA · 2021 to 2025
$2.6M
Deciphering the Role of Frizzled Receptors in Palatal DevelopmentK08DE031039 · NIDCR · VAN ANDEL RESEARCH INSTITUTE · PI MICHALSKI, MEGAN · 2021 to 2025
$546k
NIDCR NIH HHS K08 DE031039NIGMS NIH HHS R35 GM142779
6 · The paper itself

Abstract

The WNT5A-mediated Wnt/Planar Cell Polarity (Wnt/PCP) pathway plays a key role in vertebrate development, particularly in limb morphogenesis. Robinow Syndrome (RS) is a rare genetic disorder characterized primarily by craniofacial malformations and limb shortening that is linked to mutations in multiple Wnt/PCP genes. The pathogenic

Indexed as

cell polaritychondrocyte orientationCRISPR/Cas9 mouse modellimb developmentlocal misalignment score (LMS)Robinow SyndromeWnt5aWnt/PCP signaling

Identifiers

PMID41510274
PMCPMC12776500

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.