Evidence map›Paper›PMID 41510269›Full record

ArticleResearch square2025

Viral control is required for intravenous BCG-mediated protection against tuberculosis in simian immunodeficiency virus-infected macaques.

Solomon Jauro, Erica C Larson, Brendon Wahlberg, Michael C Chao, Mark A Rodgers, Janelle L Gleim, Luke E Hood, Persis S Sunny, Mallory K Collins, Jaime A Tomko and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Solomon JauroDepartment of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-5373-5727
Erica C LarsonDepartment of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Brendon WahlbergDepartment of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Michael C ChaoRagon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.ORCID https://orcid.org/0000-0003-3158-7337
Mark A RodgersDepartment of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0001-9800-3362
Janelle L GleimDepartment of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Luke E HoodDepartment of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Persis S SunnyDepartment of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Mallory K CollinsDepartment of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Jaime A TomkoDepartment of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
H Jacob BorishDepartment of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Marshall A MalinDepartment of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Pauline MaielloDepartment of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-5188-8420
Todd DemarcoDuke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.
Sarah M FortuneRagon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.ORCID https://orcid.org/0000-0001-7565-9975
Philana Ling LinCenter for Vaccine Research, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
JoAnne L FlynnDepartment of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0001-7874-8981
Charles A ScangaDepartment of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0003-3654-5603

Funding

IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB)75N93019C00071 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI FORTUNE, SARAH · 2019 to 2025
$57.3M
Practices CoreUC7AI180311 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI William Paul Duprex · 2023 to 2026
$13.2M
Preventing TB with intravenous BCG in SIV-infected macaquesR01AI155345 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCANGA, CHARLES A. · 2021 to 2025
$4.2M
NIAID NIH HHS 75N93019C00071NIAID NIH HHS HHSN272201800003CNIAID NIH HHS R01 AI155345NIAID NIH HHS UC7 AI180311
6 · The paper itself

Abstract

Tuberculosis (TB), caused by

Identifiers

PMID41510269
PMCPMC12776483

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.