Evidence map›Paper›PMID 41510198›Full record

ArticleJAC-antimicrobial resistance2026

Pharmacodynamic individualization of phage therapy against a KPC-5-producing

Thomas D Nguyen, Jacob T Sanborn, Brian M Ho, Tiffany Luong, Troy D Wood, Liang Chen, Dwayne R Roach, Nicholas M Smith

Abstract read
In one paragraph

Article in JAC-antimicrobial resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Thomas D NguyenDivision of Clinical and Translational Therapeutics, Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA.ORCID https://orcid.org/0009-0000-1069-1720
Jacob T SanbornDivision of Clinical and Translational Therapeutics, Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA.
Brian M HoDivision of Clinical and Translational Therapeutics, Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA.
Tiffany LuongDepartment of Biology, San Diego State University, San Diego, CA, USA.
Troy D WoodDepartment of Chemistry, University at Buffalo, Buffalo, NY, USA.
Liang ChenDivision of Clinical and Translational Therapeutics, Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA.ORCID https://orcid.org/0000-0001-5845-2235
Dwayne R RoachDepartment of Biology, San Diego State University, San Diego, CA, USA.
Nicholas M SmithDivision of Clinical and Translational Therapeutics, Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA.ORCID https://orcid.org/0000-0002-0212-2787

Funding

Novel Strategies for Antibiotic Combinations to Combat Gram-negative SuperbugsR01AI148560 · NIAID · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI BULITTA, JURGEN BERND, TSUJI, BRIAN · 2020 to 2024
$3.9M
Novel Combination Therapies to Combat Hypermutable Carbapenem-Resistant P. aeruginosaR01AI165997 · NIAID · UNIVERSITY OF COLORADO DENVER · PI MARK D. SUTTON, Brian Tsuji · 2022 to 2026
$3.9M
Age and Race Influences on Immunosuppression after Renal TransplantR01AG056392 · NIA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI TORNATORE, KATHLEEN M · 2018 to 2022
$3.5M
Pharmacokinetics and Pharmacodynamics of Mechanistically Aware Phage CocktailsR01AI177997 · NIAID · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Nicholas Michael Smith · 2024 to 2026
$2.2M
Aerosol delivery of combinational therapeutics targeting deadly lung infectionsR01HL167828 · NHLBI · PURDUE UNIVERSITY · PI QI ZHOU · 2024 to 2026
$1.8M
NHLBI NIH HHS R01 HL167828NIAID NIH HHS L30 AI194397NIAID NIH HHS R01 AI148560NIAID NIH HHS R01 AI165997NIAID NIH HHS R01 AI177997NIA NIH HHS R01 AG056392
6 · The paper itself

Abstract

Background: There is a resurgence of interest in bacteriophage (phage) therapy as antimicrobials, resulting from growing antimicrobial resistance to small-molecule antibiotics. Phages are bacterial viruses long studied, but there is a need for high resolution and systematic assessment of clinical dosing strategies for phages to better inform therapy. Methods: We hypothesized that empirical Results: PYO2 single-bolus administration achieved a bacterial log reduction of 6.82 log Conclusions: This highlights the potential of reverse translational pharmacokinetic/pharmacodynamic-driven approaches to guide rational phage selection strategies against individual clinical isolates while identifying potential antagonistic phage-phage interactions.

Identifiers

PMID41510198
PMCPMC12776353

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.