Evidence map›Paper›PMID 41510154›Full record

ArticleTheranostics2026

Neuron-specific WDR5 epigenetically upregulates ARID5B to impair GABAergic synaptic transmission and promotes epileptogenesis.

Juan Gu, Ping-Yang Ke, Xin-Yu Zhang, Chao Liu, Yuan Yang, Ming-Lan Yu, Zhen-Zhong Xu, Chun-Xiang Zhang, Wei Dong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Juan GuKey Laboratory of Medical Electrophysiology of Ministry of Education and Medical, Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China.
Ping-Yang KeDepartment of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Neurology Key Laboratory of Chongqing Education Commission of China, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Xin-Yu ZhangKey Laboratory of Medical Electrophysiology of Ministry of Education and Medical, Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China.
Chao LiuKey Laboratory of Medical Electrophysiology of Ministry of Education and Medical, Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China.
Yuan YangKey Laboratory of Medical Electrophysiology of Ministry of Education and Medical, Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China.
Ming-Lan YuKey Laboratory of Medical Electrophysiology of Ministry of Education and Medical, Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China.
Zhen-Zhong XuDepartment of Anesthesiology, First Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.
Chun-Xiang ZhangKey Laboratory of Medical Electrophysiology of Ministry of Education and Medical, Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China.
Wei DongKey Laboratory of Medical Electrophysiology of Ministry of Education and Medical, Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA-Binding ProteinsEpigenesis, GeneticEpilepsy, Temporal LobeIntracellular Signaling Peptides and ProteinsNeuronsSynaptic TransmissionTranscription FactorsAnimalsDisease Models, AnimalEpilepsygamma-Aminobutyric AcidHippocampusHistone-Lysine N-MethyltransferaseHistonesHumansMaleDNA-Binding Proteinsgamma-Aminobutyric Acidhistone H3 trimethyl Lys4Histone-Lysine N-MethyltransferaseHistonesIntracellular Signaling Peptides and ProteinsTranscription FactorsWdr5 protein, mouseARID5BepilepsyGABAergic synaptic transmissionH3K4me3WDR5

Identifiers

PMID41510154
PMCPMC12775672

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.