ArticleTranslational cancer research2025
Targeted next-generation sequencing reveals genomic differences between male and female breast cancer.
Article in Translational cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Compared with female breast cancer (FBC), male breast cancer (MBC) is often detected at the advanced stage and has a poorer prognosis. Due to the limited research data on MBC, its clinical diagnosis and treatment regimens are mainly based on FBC, although these regimens may not be appropriate for MBC patients. This study aimed to investigate the similarities and differences between MBC and FBC at the genetic level, in order to provide ideas and basis for the diagnosis and treatment of MBC. Methods: In this cross-sectional study, we conducted high-throughput sequencing on formalin-fixed paraffin-embedded (FFPE) samples obtained from a cohort of 12 MBC and 14 FBC patients. Utilizing bioinformatics tools, we meticulously analyzed and compared the genomic profiles to elucidate the underlying genetic distinctions between MBC and FBC. Results: In our study, Conclusions: We concluded that MBC and FBC exhibit both genomic similarities and distinctions in our study. In the context of precision medicine, this study may provide new ideas and a basis for the diagnosis and treatment of MBC.
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