Evidence map›Paper›PMID 41510104›Full record

ArticleTranslational cancer research2025

Targeting CLIC6 with theaflavin enhances radiotherapy sensitivity in ER

Mengying Suo, Lin Liu, Tiantian She, Chong Chen

Abstract read
In one paragraph

Article in Translational cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mengying SuoSchool of Medicine, Nankai University, Tianjin, China.
Lin LiuTianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China.
Tiantian SheSchool of Medical Technology, Tianjin Medical University, Tianjin, China.
Chong ChenSchool of Medicine, Nankai University, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Radiotherapy is a cornerstone of breast cancer treatment; however, estrogen receptor-positive (ER Methods: We integrated single-cell RNA sequencing (scRNA-seq) data from ER Results: The hdWGCNA identified a luminal A-like gene module correlated with progesterone receptor (PR) positivity and low Ki67 expression, within which Conclusions: This study identified CLIC6 as a novel gene associated with radioresistance in ER

Indexed as

Breast cancerchloride intracellular channel 6 (CLIC6)radiotherapy sensitivitytheaflavintumor cell

Identifiers

PMID41510104
PMCPMC12776237

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.