Evidence map›Paper›PMID 41509979›Full record

ArticleMaterials today. Bio2026

Hypoxia-specific metal-organic frameworks combined with lactate immunometabolism regulation augment anti-tumor immunity of HIFU.

Yinglin Zhou, Xinchang Huang, Tong Su, Kunli Su, Song Peng, Huanan Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yinglin ZhouDepartment of Radiology, Women and Children's Hospital of Chongqing Medical University, 400016, Chongqing, PR China.
Xinchang HuangDepartment of Radiology, Women and Children's Hospital of Chongqing Medical University, 400016, Chongqing, PR China.
Tong SuDepartment of Radiology, Women and Children's Hospital of Chongqing Medical University, 400016, Chongqing, PR China.
Kunli SuDepartment of Radiology, Women and Children's Hospital of Chongqing Medical University, 400016, Chongqing, PR China.
Song PengDepartment of Radiology, Women and Children's Hospital of Chongqing Medical University, 400016, Chongqing, PR China.
Huanan LiDepartment of Radiology, Women and Children's Hospital of Chongqing Medical University, 400016, Chongqing, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-intensity focused ultrasound (HIFU) has emerged as one of the preferred modalities for breast-conserving oncotherapy, and immune response it triggers is key to prognosis. Nevertheless, its immunotherapy efficacy is often compromised by the postoperative tumor microenvironment (TME) featured by severe hypoxia and lactate accumulation, leading to subsequent tumor recurrence and metastasis. In this work, we designed hypoxia-specific metal-organic frameworks (AMCMOFs) that co-deliver the hypoxia-activated prodrug AQ4N and CaCO

Indexed as

High-intensity focused ultrasoundHypoxia-activatedImmunotherapyLactate regulationMetal-organic frameworks

Identifiers

PMID41509979
PMCPMC12775925

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.