Evidence map›Paper›PMID 41509926›Full record

ArticleiScience2026

Myeloid-T cell proximity is prominent in healthy pregnancies with extreme fetal-maternal HLA incompatibility.

Xuezi Tian, Juliette Krop, Marieke E Ijsselsteijn, Johanna M Kapsenberg, Jacqueline D H Anholts, Lotte van der Meeren, Hailiang Mei, Michiel H J Huigen, Carin van der Keur, Dave L Roelen and 5 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xuezi TianDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Juliette KropDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Marieke E IjsselsteijnDepartment of Pathology, Leiden University Medical Center, Leiden, the Netherlands.
Johanna M KapsenbergDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Jacqueline D H AnholtsDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Lotte van der MeerenDepartment of Pathology, Leiden University Medical Center, Leiden, the Netherlands.
Hailiang MeiDepartment of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.
Michiel H J HuigenDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Carin van der KeurDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Dave L RoelenDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Lisa E E L O LashleyDepartment of Obstetrics and Gynecology, Leiden University Medical Center, Leiden, the Netherlands.
Els van BeelenDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Frits KoningDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Marie-Louise P van der HoornDepartment of Obstetrics and Gynecology, Leiden University Medical Center, Leiden, the Netherlands.
Michael EikmansDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pregnancy requires local immune tolerization. Oocyte donation (OD) pregnancies, with extensive fetal-maternal human leukocyte antigen (HLA) mismatching, are at higher risk of pre-eclampsia. We hypothesize that immune adaptations are needed at the fetal-maternal interface to maintain healthy pregnancy despite high HLA dissimilarity. By multispectral imaging, myeloid cells constituted 65% of the decidual immune cells and encompassed 12 distinct clusters. Fully-allogeneic healthy OD pregnancies displayed a higher frequency of CD163

Indexed as

immunologyomicspregnancy

Identifiers

PMID41509926
PMCPMC12774686

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.