ArticleDiabetology international2026
Discontinuation of oral semaglutide due to adverse effects: a database study on Japanese individuals with type 2 diabetes.
Article in Diabetology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Parasympathetic dysfunction assessed by deep-breathing CVR-R is associated with early discontinuation of oral semaglutide in type 2 diabetes: A multicenter retrospective study.Journal of diabetes investigation · 2026Article
- Rates of, Reasons for, and Reactions to Discontinuation of GLP-1 Receptor Agonists: A Narrative Review.Diabetes, obesity & metabolism · 2026Review
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The global prevalence of diabetes continues to rise, necessitating advancements in treatment, such as glucagon-like peptide-1 receptor agonists. While oral semaglutide has demonstrated comparable efficacy to injectable formulations, gastrointestinal symptoms remain a barrier to continued use. This study analyzed factors associated with discontinuation of oral semaglutide due to gastrointestinal symptoms in individuals newly prescribed the drug at Jikei University Hospital between 2022 and 2023. A total of 358 individuals were categorized into discontinuation (n = 65) and continuation (n = 293) groups based on continuation of treatment for at least 180 days. Logistic regression analyses identified higher HbA1c levels and metformin use as significant predictive factors for discontinuation at 3 mg. Furthermore, individuals taking metformin ≥ 1000 mg/day (high-dose metformin) exhibited a significantly higher risk of discontinuation due to gastrointestinal symptoms. In the supplementary analyses that included individuals who escalated from 3 mg to higher doses, metformin use-regardless of dose-was associated with early gastrointestinal-related discontinuation at 3 mg. No significant predictive factors were identified at 7 mg or 14 mg. These findings suggest that careful consideration should be given when initiating oral semaglutide, particularly in individuals with high HbA1c levels or those receiving metformin therapy. Supplementary Information: The online version contains supplementary material available at 10.1007/s13340-025-00868-0.
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