Evidence map›Paper›PMID 41509829›Full record

ArticleJournal of spine surgery (Hong Kong)2025

Pseudoarthrosis after thoracolumbar fusion in patients with Parkinson's disease.

Matthew Lindsey, Hannah Levy, Tyler Allen, Andrew Pumford, Abdelrahman Hamouda, Brian Kelley, Steven Girdler, Anthony Mikula, Brian Goh, Brett Freedman and 2 more

Abstract read
In one paragraph

Article in Journal of spine surgery (Hong Kong), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Matthew LindseyDivision of Spine Surgery, Department of Orthopedics, St Louis University School of Medicine, Saint Louis, MO, USA.ORCID https://orcid.org/0000-0003-3754-1866
Hannah LevyOrthopaedic Surgery Residency, Mayo Clinic, Rochester, MN, USA.
Tyler AllenOrthopaedic Surgery Residency, Mayo Clinic, Rochester, MN, USA.
Andrew PumfordMayo Clinic Alix School of Medicine, Rochester, MN, USA.
Abdelrahman HamoudaMayo Clinic Alix School of Medicine, Rochester, MN, USA.
Brian KelleyMayo Clinic Alix School of Medicine, Rochester, MN, USA.
Steven GirdlerDISC Orthopaedics, Newport Beach, CA, USA.
Anthony MikulaDepartment of Neurosurgery, Mayo Clinic, Rochester, MN, USA.
Brian GohEmory Orthopaedics and Spine Center, Atlanta, GA, USA.
Brett FreedmanDivision of Spine Surgery, Department Orthopaedic Surgery, Mayo Clinic, Rochester, MN, USA.
Arjun SebastianDivision of Spine Surgery, Department Orthopaedic Surgery, Mayo Clinic, Rochester, MN, USA.
Ahmad NassrDivision of Spine Surgery, Department Orthopaedic Surgery, Mayo Clinic, Rochester, MN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pseudoarthrosis is the most common indication for revision in spinal deformity surgery. Parkinson's disease (PD) is associated with postural instability and sagittal and coronal plane deformities. Spinal fusion in PD has a high rate of complications. The risk factors for pseudoarthrosis in PD cases are yet to be elucidated. This study identifies operative and patient factors associated with pseudoarthrosis after thoracolumbar (TL) fusion in patients with PD. Methods: In this retrospective case-control study, adult PD patients who underwent posterior TL fusion at an academic center between 2017 and 2022 were retrospectively identified. Comorbidities, functional status, PD metrics, bone and muscle quality, indications, and construct-related factors were extracted. Fusion status was assessed via continuous osseous bridging on 1-year postoperative computer-aided tomography (CT) scan. Univariate analysis compared preoperative and intraoperative variables based on fusion status. Results: Fifty-nine patients were analyzed (27% pseudoarthrosis rate). Pseudoarthrosis was associated with screw loosening (53% Conclusions: PD remains a major risk factor for poor outcomes after TL spinal fusion. Wheelchair use, lower HU, essential tremor, and trauma patients increased pseudoarthrosis rate. Pseudoarthrosis was associated with increased mortality.

Indexed as

lumbar fusionParkinson’s disease (PD)spinal fusionThoracic fusion

Identifiers

PMID41509829
PMCPMC12775613

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.