ArticleCardiovascular diagnosis and therapy2025
The value of left ventricular and left atrial strains in eosinophilic myocarditis and hypereosinophilic syndrome.
Article in Cardiovascular diagnosis and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Eosinophilia and the Heart: Evolving Concepts.Current cardiology reports · 2026Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hypereosinophilic syndrome (HES) is a rare disease characterized by persistent eosinophilia associated with organ damage, and may be complicated by eosinophilic myocarditis (EM). However, the utility of strain imaging in these conditions remains unclear. We aimed to evaluate the value of strain imaging in HES. Methods: We performed a cross-sectional study of all patients aged >18 years diagnosed with HES at Cleveland Clinic between September 1986 and January 2023. Left ventricular global longitudinal strain (LVGLS), left atrial (LA) strain, and right ventricular (RV) free wall strain were measured. The primary endpoint was a composite of stroke at diagnosis and major adverse cardiovascular events during the follow-up period. Outcomes were compared using chi-square tests. Results: Of 1,664 patients with eosinophilia, 34 patients with confirmed HES were included in the final cohort. The mean age was 57±16 years, and 58.8% were female. The median follow-up duration was 85 months. Among them, ten patients (29.4%) were diagnosed with EM and twelve patients (35.3%) developed the primary endpoint. EM patients had significantly worse LVGLS (-9.7% Conclusions: LVGLS is frequently impaired in patients with EM, and is associated with increased risk of stroke and major cardiovascular events. These findings suggest its potential as a marker of cardiac involvement and prognosis in HES.
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