Evidence map›Paper›PMID 41509521›Full record

ArticleBMJ neurology open2026

Pilot randomised controlled trial of a novel form of exercise on parkinsonism symptoms.

Benjamin Sinclair, Kelly L Bertram, Meaghan Clough, Sahan M Gamage, Lucy Vivash, Huiliang M Tang, Frederique Boonstra, Jasmine Moses, Evelyn Lindsay, Brendan Major and 9 more

Abstract read
In one paragraph

Article in BMJ neurology open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Benjamin SinclairDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0002-0850-3644
Kelly L BertramDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.
Meaghan CloughDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0001-5962-3681
Sahan M GamageDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.
Lucy VivashDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0002-1182-0907
Huiliang M TangDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.
Frederique BoonstraDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.
Jasmine MosesDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.
Evelyn LindsayDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.
Brendan MajorDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.
Sarah FanDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.
Sue VarleyDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.
Lily TurnerDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.
Owen WhiteDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0002-2836-7344
Scott KolbeDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.
Joanne FieldingDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.
Natasha A LanninDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.
Meng LawDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.
Terence J O'BrienDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Exercise-assistance strategies are useful in allowing mobility-impaired patients to access the benefits of exercise. This trial is the first of the Methods: This was a pilot, parallel-arm randomised controlled trial with assessor blinding. Participants (n=30: 22 with Parkinson's disease (PD) and 8 with atypical Parkinsonism conditions (AP)) were allocated to either experimental or control group. The experimental group received 24 sessions of 30 min on the Results: For the PD cohort, lower-body strength/coordination (5× Sit-To-Stand; b(95% CI)=-3.02 (-5.16 to -0.89), p=0.013), gait (self-selected walking speed; b=12.48 (2.18 to 22.78), p=0.029, stride length; b=9.75 (0.99 to 18.52), p=0.043) and backward walking speed (b=14.25 (1.93 to 26.57), p=0.038) were improved by the intervention. No significant effect of intervention on the outcome variables was found in the AP cohort. No serious adverse events were recorded. Median adherence to treatment was 95.8%. Interpretation: This pilot trial indicates that the

Indexed as

PARKINSON'S DISEASEREHABILITATION

Identifiers

PMID41509521
PMCPMC12778312

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.