Evidence map›Paper›PMID 41509508›Full record

ArticleEuropean heart journal open2026

Impaired SARS-CoV-2 vaccine responsiveness is not associated with subclinical atherosclerosis or cardiovascular disease.

Samuel H A Andersson, Anthi Chalou, Megan Mulholland, Pernilla Katra, Irena Ljungcrantz, Linda Andersson, Gunnar Engström, Jan Nilsson, Alexandru Schiopu, Harry Björkbacka and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Samuel H A AnderssonDepartment of Clinical Sciences, Malmö, Lund University, Jan Waldenströms Gata 35, CRC 91:12, Box 50 332, Malmö, 202 13, Sweden.
Anthi ChalouDepartment of Clinical Sciences, Malmö, Lund University, Jan Waldenströms Gata 35, CRC 91:12, Box 50 332, Malmö, 202 13, Sweden.
Megan MulhollandDepartment of Clinical Sciences, Malmö, Lund University, Jan Waldenströms Gata 35, CRC 91:12, Box 50 332, Malmö, 202 13, Sweden.ORCID https://orcid.org/0000-0002-3352-0403
Pernilla KatraDepartment of Clinical Sciences, Malmö, Lund University, Jan Waldenströms Gata 35, CRC 91:12, Box 50 332, Malmö, 202 13, Sweden.
Irena LjungcrantzDepartment of Clinical Sciences, Malmö, Lund University, Jan Waldenströms Gata 35, CRC 91:12, Box 50 332, Malmö, 202 13, Sweden.
Linda AnderssonDepartment of Clinical Sciences, Malmö, Lund University, Jan Waldenströms Gata 35, CRC 91:12, Box 50 332, Malmö, 202 13, Sweden.
Gunnar EngströmDepartment of Clinical Sciences, Malmö, Lund University, Jan Waldenströms Gata 35, CRC 91:12, Box 50 332, Malmö, 202 13, Sweden.ORCID https://orcid.org/0000-0002-8618-9152
Jan NilssonDepartment of Clinical Sciences, Malmö, Lund University, Jan Waldenströms Gata 35, CRC 91:12, Box 50 332, Malmö, 202 13, Sweden.ORCID https://orcid.org/0000-0002-9752-7479
Alexandru SchiopuDepartment of Translational Medicine, Cardiac Inflammation Research, Lund University, Jan Waldenströms Gata 35, CRC 60:13, Box 50 332, Malmö, 202 13, Sweden.ORCID https://orcid.org/0000-0002-7587-5050
Harry BjörkbackaDepartment of Clinical Sciences, Malmö, Lund University, Jan Waldenströms Gata 35, CRC 91:12, Box 50 332, Malmö, 202 13, Sweden.ORCID https://orcid.org/0000-0003-3918-0857
Daniel EngelbertsenDepartment of Clinical Sciences, Malmö, Lund University, Jan Waldenströms Gata 35, CRC 91:12, Box 50 332, Malmö, 202 13, Sweden.ORCID https://orcid.org/0000-0002-0289-5210

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Although age-related immune deterioration has been implicated as a mechanistic contributor to cardiovascular disease (CVD), evidence for an impairment of adaptive immune function in individuals with clinically verified presence of atherosclerosis is lacking. Methods and results: To test the association between atherosclerosis and immune function, we evaluated SARS-CoV-2 vaccine responsiveness in 65- to 71-year-old individuals ( Conclusions: Our study demonstrates that subclinical atherosclerosis or prevalent CVD is not associated with impaired responsiveness to vaccination.

Indexed as

AtherosclerosisImmunityVaccination

Identifiers

PMID41509508
PMCPMC12777980

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.